Evidence map›Paper›PMID 42469834›Full record

ArticleBMC veterinary research2026

Role of vimentin in inhibiting akabane virus replication and its preliminary exploration of mechanisms involving autophagy and apoptosis.

Miaomiao Zhang, Yajie Zheng, Sifan Wang, Dengshuai Zhao, Limei Qin, Han Gao, Gan Li, Shikai Cai, Zhihao Li, Xiaolin Lan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miaomiao Zhang *Guangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Yajie Zheng *Guangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Sifan WangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Dengshuai ZhaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Limei QinGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Han GaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Gan LiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Shikai CaiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Zhihao LiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Xiaolin LanGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Fang LiangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China.
Mengmeng ZhaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China. mengmengzhao2021@fosu.edu.cn.
Keshan ZhangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528231, China. zks009@126.com.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515140152National Key Research and Development Program Projects 2023YFD1801302, 2023YFD1801301Research Start-up Project for High-level Talents of Foshan University CGZ07001Research Start-up Project for High-level Talents of Foshan University CGZ07465Special Funds for Rural Revitalization Strategy of Guangdong Provincial Department of Agriculture and Rural Affairs in 2024 2024CXTD15
6 · The paper itself

Abstract

AKAV (Akabane virus), as a mosquito-borne virus, can cause abortions and stillbirths in pregnant ruminants, posing a threat to the global livestock industry. Vimentin (VIM), a key component of the IF cytoskeleton, plays a crucial role in viral infection by facilitating viral entry and modulating host antiviral responses. Dynamic changes in VIM transcription and protein expression levels were assessed longitudinally following infection and under varying multiplicities of infection using qRT-PCR and WB. The effects of VIM on viral replication were assessed in both VIM-overexpressing and knockout MA-104 cells through qRT-PCR, WB, TCID

Indexed as

ApoptosisAutophagyBunyaviridae InfectionsOrthobunyavirusVimentinVirus ReplicationAnimalsCattleCell LineVimentinAkabane virusKnockoutOverexpressionVimentinViral replication

Identifiers

PMID42469834
PMCPMC13688986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.