Evidence map›Paper›PMID 42469773›Full record

ReviewMolecular cancer2026

Breaking barriers: nano-boosted drug delivery systems in overcoming the defenses of pancreatic cancer.

Yujia Wang, Yuxin Zhang, Xueyan Wang, Wei Zhao, Qiuyi Li, Minglu Zhou, Ying Liu, Xiaoli Yi, Jinhan He, Yanping Li and 1 more

Abstract readReview
In one paragraph

Review in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujia Wang *Department of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuxin Zhang *Department of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Xueyan Wang *Department of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Wei ZhaoDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiuyi LiDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Minglu ZhouDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Ying LiuDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaoli YiDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Jinhan HeDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China.
Yanping LiDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China. liyanping_512@163.com.
Jie ZhouDepartment of Pharmacy, Department of Cardiovascular Surgery, Institute of Metabolic Diseases and Pharmacotherapy, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, China. zhoujie123456@wchscu.cn.

Funding

China Postdoctoral Science Foundation 2025M770208Innovation Group Project from Science & Technology Department of Sichuan Province 2023NSFSC1993National Natural Science Foundation of China 32101145National Natural Science Foundation of China 32501198National Natural Science Foundation of China 82204297National Natural Science Foundation of China 82304395National Natural Science Foundation of China 82304399Qimingxing" Research Fund for Young Talents of West China Hospital HXQMX0030Qimingxing" Research Fund for Young Talents of West China Hospital HXQMX0109Qimingxing" Research Fund for Young Talents of West China Hospital HXQMX0110Sichuan Provincial Science and Technology Support Program 2024NSFSC1665Sichuan Provincial Science and Technology Support Program 2024NSFSC1739
6 · The paper itself

Abstract

Pancreatic cancer (PC) remains a highly lethal malignancy presenting formidable therapeutic challenges, primarily attributable to the substantial barriers posed by its dense desmoplastic stroma, profoundly immunosuppressive microenvironment, and poor drug bioavailability. Nanotechnology offers an effective strategy to enhance therapeutic efficacy through improved targeting, optimized pharmacokinetics, enhanced tissue penetration, increased biosafety, and high clinical translational potential. Consequently, this nanotechnology-based platform has been extensively investigated over the past decade for treating PC. This review examines a comprehensive overview of nanoparticle-mediated delivery systems for targeted PC therapy, critically evaluating recent developments and ongoing hurdles along the bench-to-bedside pathway. We discuss applications across chemotherapy, immunotherapy, gene therapy, and other modalities employed as monotherapies or combination regimens.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsNanoparticle Drug Delivery SystemNanoparticlesPancreatic NeoplasmsAnimalsHumansImmunotherapyNanomedicineNanotechnologyTumor MicroenvironmentAntineoplastic AgentsNanoparticle Drug Delivery SystemBarriersNanomedicineNanotechnologyPancreatic cancerTreatment

Identifiers

PMID42469773
PMCPMC13670678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.