Evidence map›Paper›PMID 42469736›Full record

ArticleBMC pulmonary medicine2026

Cumulative intraoperative oxygen exposure acts as a predictor for postoperative acute exacerbation of interstitial lung disease: a retrospective cohort study.

Ryotaro Katsuya, Naoki Ozeki, Tomohito Okubo, Kiichi Tatakawa, Chihiro Furuta, Hideaki Note, Toyofumi Fengshi Chen-Yoshikawa, Takayuki Fukui

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ryotaro KatsuyaDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Naoki OzekiDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. naokiozeki@aichi-med-u.ac.jp.ORCID https://orcid.org/0000-0001-9473-8353
Tomohito OkuboDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kiichi TatakawaDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Chihiro FurutaDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Hideaki NoteDepartment of Anesthesia, Aichi Medical University, Nagakute, Japan.
Toyofumi Fengshi Chen-YoshikawaDepartment of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takayuki FukuiDivision of Chest Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive oxygen administration during surgery may induce lung damage via oxidative stress; however, limited evidence exists on how intraoperative oxygen usage and preoperative pulmonary function predict acute exacerbation (AE) in patients with interstitial lung disease (ILD). This study evaluated whether intraoperative oxygen use and preoperative pulmonary function could predict postoperative AEs in patients with ILD who underwent lung surgery.

methodsWe retrospectively analyzed 78 patients with ILD who underwent lung surgery between 2014 and 2022. Clinical variables, including intraoperative oxygen usage and preoperative pulmonary function tests, were assessed for their association with AEs occurring within 1 month (1mAE) and 1 year (1yAE) postoperatively using Firth's bias-reduced logistic regression.

resultsEight patients (10%) had 1mAE, and 14 (18%) had 1yAE. Multivariable analysis showed that lower %vital capacity (%VC) consistently predicted both 1mAE and 1yAE, whereas lower %diffusing capacity for carbon monoxide (%DLCO) significantly predicted only 1yAE. Notably, total oxygen administration > 990 L exhibited a marginal association with 1mAE (OR 2.12, 95% CI: 0.93-4.99, p = 0.071). Even after adjusting for operative and anesthesia durations, total oxygen volume remained a significant independent predictor for 1yAE (OR 2.29, 95% CI: 1.09-4.93, p = 0.029). No significant associations were found between AEs and factors such as the mean fraction of inspired oxygen (FiO

conclusionsCumulative intraoperative oxygen administration (rather than mean FiO2) serves as an independent predictor of long-term postoperative AEs in patients with ILD. These findings suggest that cumulative oxygen exposure may contribute to long-term postoperative risk through mechanisms related to oxidative stress.

trial registrationAichi Medical University 2025-011.

Indexed as

Intraoperative CareLung Diseases, InterstitialOxygenOxygen Inhalation TherapyPostoperative ComplicationsAgedDisease ProgressionFemaleHumansLogistic ModelsMaleMiddle AgedRespiratory Function TestsRetrospective StudiesOxygenAcute exacerbationInterstitial lung diseaseOxygenPulmonary function

Identifiers

PMID42469736
PMCPMC13660226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.