Evidence map›Paper›PMID 42469717›Full record

ArticleBMC women's health2026

Pregnancy history is associated with lower odds of osteoporosis among Taiwanese women.

Yuen-En Chang, Song-Shan Huang, Chueh-Yi Huang, Chia-Lung Shih

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Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Yuen-En Chang *Deparment of Nursing, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.
Song-Shan Huang *Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.
Chueh-Yi HuangDepartment of Obstetrics and Gynecology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.
Chia-Lung ShihClinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, No. 539, Zhongxiao Rd., East Dist., Chiayi City, 600566, Taiwan. stone770116@gmail.com.ORCID http://orcid.org/0000-0002-5295-6667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporosis is a major public health concern worldwide. Although female reproductive factors have been suggested to influence bone health, their associations with osteoporosis remain inconclusive.

objectiveThis study aimed to investigate the associations between reproductive characteristics and the odds of osteoporosis in Taiwanese women.

methodsWe conducted a cross-sectional analysis using data from women randomly selected from the Taiwan Biobank. Bone mineral density (BMD) status was classified into three categories according to the World Health Organization (WHO) criteria: normal BMD (T-score > - 1.0), osteopenia (- 2.5 < T-score ≤ - 1.0), and osteoporosis (T-score ≤ - 2.5). Univariable and multivariable logistic regression analyses were performed to assess the association between reproductive factors and the odds of BMD status.

resultsAmong the 4,854 participants, 3,107 (64.0%) were classified as having normal BMD, 1,374 (28.3%) as having osteopenia, and 373 (7.7%) as having osteoporosis. Univariate analysis showed that a history of pregnancy was associated with a higher odd of osteopenia (odds ratio [OR] = 1.946, 95% CI: 1.589-2.382, p < 0.001), osteoporosis (OR = 1.825, 95% CI: 1.288-2.586, p = 0.001), and low BMD level (T-score < -0.1) (OR = 1.919, 95% CI: 1.597-2.306, p < 0.001). After adjusting for known confounders, pregnancy history was associated with a lower odd of osteoporosis (adjusted OR = 0.644, 95% CI: 0.422-0.981, p = 0.041), but not significantly associated with the odds of osteopenia or low BMD level.

conclusionsPregnancy history was independently associated with lower odds of osteoporosis among Taiwanese women after adjustment for known confounding factors. However, given the cross-sectional nature of this study, causal relationships cannot be established. Future longitudinal studies are warranted to validate this finding.

Indexed as

Bone DensityBone Diseases, MetabolicOsteoporosisReproductive HistoryAdultAgedCross-Sectional StudiesFemaleHumansLogistic ModelsMiddle AgedOdds RatioPregnancyRisk FactorsTaiwanMenopauseOsteoporosisPregnancySecondhand smokeTea consumption

Identifiers

PMID42469717
PMCPMC13660322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.