Evidence map›Paper›PMID 42469614›Full record

ArticleBMC genomics2026

The neuronal A-to-I RNA editome of Solenopsis invicta expands conserved recoding repertoire between two ant species.

Jiyao Liu, Ling Ma, Qiuhua Xie, Wanzhi Cai, Hu Li, Fenghao Liu, Youming Hou, Lu Peng, Yuange Duan

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Jiyao Liu *State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Ling Ma *State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Qiuhua Xie *State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Wanzhi CaiState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Hu LiState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Fenghao LiuState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Youming HouState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Lu PengState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Yuange DuanState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China. duanyuange@cau.edu.cn.ORCID https://orcid.org/0000-0003-2311-9859

Funding

Chinese Universities Scientific Fund 2026RC003Chinese Universities Scientific Fund 2026TC089Joint Research Program of State Key Laboratory of Agricultural and Forestry Biosecurity SKLJRP2503Natural Science Foundation of Beijing Municipality 6252012
6 · The paper itself

Abstract

backgroundA-to-I RNA editing expands proteomic diversity and may contribute to caste-specific phenotypic plasticity in eusocial insects. However, the quantity-accuracy trade-off in editing detection usually hinders comprehensive characterization of the RNA editome. MATERIALS AND

methodsTo overcome the quantity-accuracy trade-off, we first perform de novo identification of the neuronal A-to-I editome of the red imported fire ant Solenopsis invicta, and then apply an orthology-based strategy to project candidate editing sites to another ant species Acromyrmex echinatior.

resultsWe obtain nearly 3000 editing sites in S. invicta, including 91 nonsynonymous (recoding) sites enriched in neuronal functions such as synaptic transmission, ion channels, and circadian rhythms. The orthology-based strategy substantially expands the previously known recoding repertoire in the leaf-cutting ant A. echinatior, reveals many previously missed recoding sites and edited genes, and uncovers additional caste-specific recoding events between gynes and workers, highlighting conserved, potentially functional editing targets across ant evolution. Representative recoding sites are validated by Sanger sequencing.

conclusionOur work expands ant RNA editome resources and identifies conserved recoding candidates that may facilitate future studies of eusocial caste diversification, neuronal function, and phenotypic plasticity.

Indexed as

AntsFire AntsNeuronsRNA EditingAnimalsEvolution, MolecularSpecies SpecificityAnt neuronal editomeA-to-I RNA editingCaste-specific recodingConservationEusociality

Identifiers

PMID42469614
PMCPMC13663048

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