ArticleVirus genes2026
Mitochondrial cytochrome b motif architecture predicts host-specific genomic vulnerability across vertebrate species.
Article in Virus genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mitochondrial DNA (mtDNA) plays a pivotal role in cellular bioenergetics, immune regulation, and evolutionary adaptation, making it a uniquely informative genomic system for studying host-pathogen interactions. The cytochrome b (cyt b) gene, one of the most conserved mitochondrial protein-coding loci, is widely recognized for its utility in species identification, phylogenetics, and molecular evolution [1-3]. However, its potential role in shaping comparative host susceptibility to infectious diseases remains underexplored. In this study, we re-analyzed PCR-RFLP-derived mitochondrial cyt b restriction profiles targeting CCNNGG, GTAC, AGCT, TTAA, and CGCG motifs across seven vertebrate hosts: cattle, buffalo, pig, goat, rabbit, chicken, and quail. These motif architectures were compared with documented susceptibility patterns for Pasteurellosis, foot-and-mouth disease (FMD), Rinderpest, and Sarcoptes scabiei infestation [4, 6, 7]. The integrated motif matrix revealed distinct host-specific restriction profiles and four comparative genomic vulnerability clades. The findings support a model in which conserved mitochondrial motif architecture may reflect evolutionary genomic signatures relevant to pathogen-host range and susceptibility. The study is intended as a comparative genomic framework and does not claim direct causality between single restriction motifs and disease outcome.
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