Evidence map›Paper›PMID 42469531›Full record

ArticleJournal of neurology2026

Sensitivity of the UT-Hopkins Score in 350 patients with antibody-mediated autoimmune encephalitis.

Pauline Dumez, Marion Le Maréchal, Marie Benaiteau, Chloé Buttard, Elise Peter, Bastien Joubert, Hanna Hutten, Florian Lamblin, Lucia Campetella, Macarena Villagràn-Garcia and 5 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pauline DumezFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.ORCID http://orcid.org/0009-0000-0111-4219
Marion Le MaréchalUniversité Grenoble Alpes, Inserm, CHU Grenoble Alpes, Grenoble Institut des Neurosciences (GIN), Grenoble, France.
Marie BenaiteauFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Chloé ButtardFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Elise PeterFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Bastien JoubertFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Hanna HuttenLeiden University Medical Center (LUMC), Leiden, The Netherlands.
Florian LamblinFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Lucia CampetellaFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Macarena Villagràn-GarciaFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
Géraldine PicardFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France.
John ProbascoJohns Hopkins Encephalitis Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arun VenkatesanJohns Hopkins Encephalitis Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rodrigo HasbunDepartment of Infectious Diseases, UT Health McGovern Medical School, Houston, TX, USA.
Jérôme HonnoratFrench Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France. jerome.honnorat@chu-lyon.fr.ORCID http://orcid.org/0000-0002-4721-5952

Funding

Agence Nationale de la Recherche ANR-18-RHUS-0012Labex Cortex ANR-11-LABX-0042
6 · The paper itself

Abstract

backgroundEarly recognition of autoimmune encephalitis (AE) is critical but remains challenging because of overlapping clinical features with viral encephalitis (VE) and delays in antibody testing. The UT-Hopkins Score was recently developed to assist in the clinical differentiation of AE from VE at presentation. We aimed to assess the sensitivity of this score in a large national cohort of antibody-mediated AE and across major antibody-defined subgroups.

methodsWe conducted a retrospective cohort study including 350 patients with antibody-mediated AE diagnosed according to international consensus criteria at the French Reference Center. Antibodies included anti-N-methyl-D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), γ-aminobutyric acid type B receptor (GABA

resultsOverall, 90.3% (95% CI, 86.7-93.0) of patients scored ≥ 2. In the reweighted model, sensitivity increased to 92.9% (95% CI, 86.3-96.6). Sensitivity was highest in GAD65 (100%) and NMDAR (99%) subgroups, remained high in LGI1 (94%) and CASPR2 (90%), but was lower in GABA

conclusionsIn this large cohort of antibody-mediated AE, the UT-Hopkins Score demonstrated high sensitivity across most antibody subtypes, supporting its use to detect autoimmune causes early in patients presenting with encephalitis.

Indexed as

AutoantibodiesAutoimmune Diseases of the Nervous SystemEncephalitisHashimoto DiseaseAdolescentAdultAgedFemaleGlutamate DecarboxylaseHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedNerve Tissue ProteinsReceptors, GABA-Banti-leucine-rich glioma-inactivated 1 autoantibodyAutoantibodiesCNTNAP2 protein, humanGlutamate DecarboxylaseIntracellular Signaling Peptides and ProteinsLGI1 protein, humanMembrane ProteinsNerve Tissue ProteinsReceptors, GABA-BReceptors, N-Methyl-D-AspartateAntibody-mediated encephalitisAutoimmune encephalitisDiagnostic scoreEncephalitis differential diagnosis

Identifiers

PMID42469531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.