Evidence map›Paper›PMID 42469482›Full record

ArticleJournal of neurology2026

Profiling circulating Tau and phospho-Tau isoforms in pediatric and adult spinal muscular atrophy identifies selective elevation of pTau-262 in adults.

Leillani L Ha, Sunayana Mitra, Doreen T Ho, Becky Fillingham, James D Berry, Kathryn J Swoboda, Christiano R R Alves

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Leillani L HaDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Sunayana MitraDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Doreen T HoSean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Becky FillinghamSean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James D BerrySean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kathryn J SwobodaDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Christiano R R AlvesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA. CRA92@pitt.edu.ORCID http://orcid.org/0000-0002-2646-9689

Funding

Therapeutic Opportunities in Spinal Muscular AtrophyR01HD054599 · NICHD · UNIVERSITY OF UTAH · PI SWOBODA, KATHRYN J. · 2007 to 2011
$1.5M
Development of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular AtrophyK01NS134784 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christiano Alves · 2024 to 2026
$726k
Neural and non-neural contributions to phenotype in human SMA type 1R21NS108015 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SWOBODA, KATHRYN J. · 2018 to 2019
$463k
NICHD NIH HHS R01 HD054599NIH HHS K01NS134784NIH HHS R01HD054599NIH HHS R21NS108015NINDS NIH HHS K01 NS134784NINDS NIH HHS R21 NS108015
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42469482
PMCPMC13379459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.