Evidence map›Paper›PMID 42469428›Full record

ArticleNature ecology & evolution2026

Genomic and evolutionary basis of parthenogenesis in a disease-vector tick species.

Qiang Lyu, Kuang Sheng, Hong Zhou, Jingkai Ji, Miao Wang, Feng Wang, Moujian Guo, Kun Cai, Bing Hu, Kaixiao Nie and 9 more

Abstract read
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In one paragraph

Article in Nature ecology & evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qiang LyuKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0002-7631-1484
Kuang ShengZhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University, Hangzhou, China.
Hong ZhouKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0002-8164-0020
Jingkai JiKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0002-9264-7746
Miao WangKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.
Feng WangZhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University, Hangzhou, China.
Moujian GuoRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kun CaiInstitute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Bing HuInstitute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Kaixiao NieKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.
Ruiling ZhangSchool of Basic Medical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.
Shutong YueRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaobo LiAnnoroad Gene Technology, Beijing, China.ORCID http://orcid.org/0000-0002-4984-0081
Cixiu LiKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0001-6911-9489
Xun ZhouAnnoroad Gene Technology, Beijing, China.
Edward C HolmesSchool of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9596-3552
Jinfeng ChenState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-5628-6322
Liangsheng ZhangZhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0003-1919-3677
Weifeng ShiKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China. shiwf@ioz.ac.cn.ORCID http://orcid.org/0000-0002-8717-2942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haemaphysalis longicornis is an important tick species and pathogen vector characterized by the co-circulation of triploid parthenogenetic and diploid bisexual strains. However, the evolutionary basis of parthenogenesis in this species is unclear. Here we report reference-quality, haplotype-resolved genome assemblies of the parthenogenetic strain and two reference-quality genomes of the bisexual strains. Comparative genomic analysis revealed high collinearity between the parthenogenetic and bisexual genomes, with a stable chromosomal architecture maintained among the three haplotypes of the parthenogenetic strain. The parthenogenetic H. longicornis genome exhibited a major expansion in cell cycle-related gene families, including the inhibitor of apoptosis protein (IAP) family, but was characterized by a contraction in other gene families. Population resequencing of 179 individuals revealed two distinct subpopulations, with chromosome 7 harbouring high genetic differentiation and several candidate genes probably associated with parthenogenesis. Functional experiments showed that knockdown of the BIRC5 gene, a member of the IAP family, suppressed oviposition in both strains, with the parthenogenetic strain exhibiting milder adverse effects probably due to a stronger transcriptional response. Overall, our results reveal the genomic and evolutionary features associated with polyploid parthenogenesis in H. longicornis.

Indexed as

Biological EvolutionEvolution, MolecularGenomeHaemaphysalis longicornisParthenogenesisAnimalsFemale

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.