ArticlePflugers Archiv : European journal of physiology2026
Electrophysiological characterization of neuropeptide S-expressing neurons in the periLC: influence of the female estrous cycle on neuronal excitability in mice.
Article in Pflugers Archiv : European journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuropeptide S (NPS) signaling is critically involved in arousal, sleep-wake regulation, fear and anxiety, and related forms of learning and memory, yet comparatively little is known about whether intrinsic properties of identified NPS neurons differ between sexes or fluctuate across the female estrous cycle. Here, we performed whole-cell patch-clamp recordings from genetically identified NPS-eGFP neurons in acute horizontal brainstem slices containing the peri-locus coeruleus (periLC) region. We show that periLC NPS neurons can be subdivided into two electrophysiologically distinct classes based on their discharge patterns from hyperpolarized membrane potentials: a delayed-onset firing phenotype (type I) and a regular-spiking phenotype (type II). Pharmacological and voltage-clamp analyses indicate that differential contribution of a transient A-type potassium current (I
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