ArticleScientific reports2026
Synthesis of methyldopa-copper nanoparticles with laccase mimics activity for colorimetric detection of norepinephrine.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Copper-based nanozymes are increasingly used as artificial laccases, yet most rely on simple catechol ligands such as dopamine or gallic acid which provide limited control over metal coordination geometry and stability. In this work, we introduce methyldopa as a biomimetic bidentate ligand whose dual catechol-amine functionality closely reproduces the coordination environment of natural multicopper oxidases. This molecular design enables electronic tuning of the Cu(I)/Cu(II) redox cycle resulting in enhanced substrate affinity and exceptional thermal resilience. The prepared polymethyldopa-Cu nanoparticles (PMD-Cu NPs) exhibit robust laccase-like activity under near-physiological conditions catalyzing the oxidation of norepinephrine without additional oxidants. Beyond catalysis, the oxidation process provides an intrinsic colorimetric signal allowing simultaneous quantification and degradation of catecholamine pollutants as pyrogallol. Kinetic analysis (K
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