Evidence map›Paper›PMID 42469240›Full record

ArticleNature communications2026

Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis.

Marcos Gonzalez Lopez, Kaitlin A Katsura, Vitor C M Neves, Ruslan Soldatov, Josef Lavicky, Maryam Azam, Michaela Kavkova, Klara Cigosova, Brian Temsamrit, Johnny Bonnardel and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marcos Gonzalez LopezDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-8755-0827
Kaitlin A KatsuraDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Vitor C M NevesRestorative Dentistry Unit, The School of Clinical Dentistry, University of Sheffield, Sheffield, UK.ORCID 0000-0002-5111-269X
Ruslan SoldatovDepartment of Epidemiology and Biostatistics, Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5670-5881
Josef LavickyDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0001-6177-2352
Maryam AzamDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0009-0001-3292-7068
Michaela KavkovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Klara CigosovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0009-0004-9848-7407
Brian TemsamritDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Johnny BonnardelCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Hannah GongDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kelsey M NemecDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Frederick Christian BennettDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-2570-0620
Haneen TuaimaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Val YianniCentre for Craniofacial and Regenerative Biology, FoDOCS, King's College London, London, UK.ORCID 0000-0001-9857-7577
Paul T SharpeCentre for Craniofacial and Regenerative Biology, FoDOCS, King's College London, London, UK.ORCID 0000-0003-2116-9561
Marc BajenoffCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Peter KharchenkoDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6036-5875
Mariko L BennettDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Igor AdameykoDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. igor.adameyko@meduniwien.ac.at.ORCID 0000-0001-5471-0356
Jan KrivanekDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. jan.krivanek@med.muni.cz.ORCID 0000-0002-7590-187X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) SFB F78Grantová Agentura České Republiky (Grant Agency of the Czech Republic) 25-18087SNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The role of macrophages in teeth, beyond their function in innate immunity, remains unexplored. This study demonstrates that macrophages populate dental tissues during early development and increase in number during pre-eruptive stages postnatally. In continuously growing teeth, they are associated with epithelial and mesenchymal stem cell niches throughout lifetime. To investigate their role in development, we genetically disrupt macrophage migration using neural-crest specific Wnt1

Indexed as

HomeostasisMacrophagesOdontogenesisToothAnimalsCell MovementDental EnamelDentinMesenchymal Stem CellsMiceMice, KnockoutOsteogenesisReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating FactorTooth EruptionCsf1r protein, mouseReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID42469240
PMCPMC13379590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.