Evidence map›Paper›PMID 42469239›Full record

ArticleNature communications2026

Misregulation of T-box transcription factors drives BNP-NPR1 signalling underlying chronic itch.

Xiaolong Dai, Michael Kitching, Wenke Cheng, Rengang Luo, Lianlian Li, Renkai Zhu, Chunxu Shan, Weiwei Chen, Timo Buhl, Andrea Szegedi and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaolong DaiSchool of Life Sciences, Henan University, Kaifeng, Henan, China.
Michael KitchingSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland.
Wenke ChengSchool of Life Sciences, Henan University, Kaifeng, Henan, China.
Rengang LuoSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland.
Lianlian LiSchool of Life Sciences, Henan University, Kaifeng, Henan, China.
Renkai ZhuSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland.
Chunxu ShanSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland.
Weiwei ChenSchool of Life Sciences, Henan University, Kaifeng, Henan, China. 40050006@henu.edu.cn.ORCID http://orcid.org/0000-0002-1965-7606
Timo BuhlDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-3139-129X
Andrea SzegediDepartment of Dermatology, Centre of Excellence, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Jorg BuddenkotteDepartment of Dermatology and Venereology, Hamad Medical Corporation, Doha, Qatar.
Shouming XuSchool of Life Sciences, Henan University, Kaifeng, Henan, China.
Jiafu WangSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland. Jiafu.wang@dcu.ie.ORCID http://orcid.org/0000-0002-3654-4400
Jianghui MengSchool of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland. Jianghui.meng@dcu.ie.ORCID http://orcid.org/0000-0002-3107-4200

Funding

Science Foundation Ireland (SFI) 23/FFP-A/11956
6 · The paper itself

Abstract

Chronic itch poses a significant clinical burden, with activation of the brain natriuretic peptide (BNP) pathway as a hallmark, though its transcriptional control remains unclear. We identify T-box transcription factor 20 (TBX20) as upregulated in skin of atopic dermatitis patients, with increased expression in NPR1

Indexed as

Natriuretic Peptide, BrainPruritusReceptors, Atrial Natriuretic FactorT-Box Domain ProteinsAnimalsChronic DiseaseDermatitis, AtopicFemaleHumansInterleukin-13Interleukin-4KeratinocytesMaleMiceMice, KnockoutPromoter Regions, Geneticatrial natriuretic factor receptor AInterleukin-13Interleukin-4Natriuretic Peptide, BrainReceptors, Atrial Natriuretic FactorT-Box Domain Proteins

Identifiers

PMID42469239
PMCPMC13493844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.