Evidence map›Paper›PMID 42469230›Full record

ArticleCell death & disease2026

Stromal BMP signalling maintains stem cell genome integrity and prevents gastric cancer initiation.

Zihao Li, Zhengting Wang, Ruichen Yang, Jiarui Zhao, Shaoyang Zhang, Liuchun Feng, Haiyu Shen, Hua Yue, Zhenlin Zhang, Xiaolin Guo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zihao Li *Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Zhengting Wang *Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0001-5533-5711
Ruichen Yang *Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Jiarui ZhaoBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Shaoyang ZhangBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Liuchun FengBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Haiyu ShenBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Hua YueDepartment of Osteoporosis and Bone Diseases, Shanghai Clinical Research Center of Bone Diseases, Shanghai Jiao Tong University of Medicine Affiliated Sixth People's Hospital, Shanghai, China.
Zhenlin ZhangDepartment of Osteoporosis and Bone Diseases, Shanghai Clinical Research Center of Bone Diseases, Shanghai Jiao Tong University of Medicine Affiliated Sixth People's Hospital, Shanghai, China.ORCID http://orcid.org/0000-0002-7052-9722
Xiaolin GuoInstitute for Translational Medicine on Cell Fate and Disease, Shanghai Ninth People's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Department of Pathophysiology, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dengli HongInstitute for Translational Medicine on Cell Fate and Disease, Shanghai Ninth People's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Department of Pathophysiology, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5251-0297
Yuji MishinaSchool of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6268-4204
Ye-Guang ChenState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
Qiang WuThe State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology. Avenida Wai Long, Taipa, Macau SAR, China.
Huijuan LiuBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China. liuhj@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-8801-4815
Baojie LiBio-X Institutes, Shanghai Jiao Tong University, Shanghai, China. libj@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-3913-1062

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32230045National Natural Science Foundation of China (National Science Foundation of China) 92268101
6 · The paper itself

Abstract

Gastric cancer primarily originates from gastric stem/progenitor cells and is driven by somatic mutations. Although Helicobacter pylori is the main risk factor, how it drives malignancy is still not well understood. Analysis of single-cell RNA sequencing data reveals that human gastric cancer correlates with suppressed BMP signalling, a crucial niche signal for gastric stem cells, in stromal cells rather than epithelial cells. Genetic disruption of BMP signalling in Col1a2

Indexed as

Bone Morphogenetic ProteinsStem CellsStomach NeoplasmsStromal CellsAnimalsCarcinogenesisDNA DamageHelicobacter pyloriHumansMiceNeoplastic Stem CellsSignal TransductionBone Morphogenetic Proteins

Identifiers

PMID42469230
PMCPMC13658785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.