ArticleTranslational psychiatry2026
Cross-sectional and longitudinal analysis of prefrontal intermittent theta-burst stimulation-evoked hemodynamic responses in major depressive disorder.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prefrontal theta burst stimulation (TBS) - induced brain activation may offer insights into the therapeutic mechanisms underlying TBS. This study aimed to compare baseline TBS-induced prefrontal hemodynamic responses in individuals with major depressive disorder (MDD) and healthy controls (HCs), and to evaluate whether changes in stimulation-evoked responses are correlated with improvements in depressive symptoms following four weeks of daily TBS. Both MDD (n = 44; 70% females) and HCs (n = 45; 60% females) underwent a concurrent TBS/functional near-infrared spectroscopy (fNIRS) paradigm. MDD participants further received 20 sessions of intermittent TBS (iTBS) of the left dorsolateral prefrontal cortex, followed by post-treatment TBS/fNIRS measurements. TBS-evoked hemodynamic responses were analyzed using repeated-measures ANOVA and t-tests. Additionally, correlation analyses were conducted to assess the relationship between depressive symptom changes and prefrontal hemodynamic response changes following treatment. Significant increases in deoxyhemoglobin concentrations were observed both during and after TBS. However, no significant differences in TBS-induced hemoglobin responses were found between MDD participants and HCs. Notably, changes in individual TBS-induced hemodynamic responses after treatment significantly correlated with symptom reductions (r = -0.488, p = 0.037). These findings suggest that TBS-induced hemodynamic responses may reflect underlying neural changes that are functionally relevant to symptom improvement, highlighting their potential as neuroimaging markers for treatment monitoring in depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.