ArticleNature communications2026
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin.Current opinion in neurobiology · 2026Review
- Microglia-mediated neuroinflammation in Alzheimer's disease: mechanisms and emerging therapeutic targets.Frontiers in cellular neuroscience · 2026Review
- CSF estrogens' relationships to neuroinflammatory markers and brain networks in middle-aged and older black and white women.Journal of neuroinflammation · 2025Article
Corrections and comments
- Update of
Authors and funding
50 authors.
Roger B Dodd *Cambridge Institute for Medical Research, Cambridge, UK.ORCID http://orcid.org/0000-0003-4268-1863
Masahiro Enomoto *Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Ye Zhou *Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Kanayo Satoh *Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9684-239X
Yalun Zhang *Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Fusheng Chen *Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Beatrice AchesonDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Deniz GhaffariDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5567-9581
Elizabeth Sayn-WittgensteinDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0006-7497-3878
Jamie J ManningDepartment of Psychiatry and Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-6945-2254
George V DukasDepartment of Psychiatry and Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0009-0002-9738-9421
Ronak PatelCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Alondra Schweizer BurgueteCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mason J KralovecCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mamunur RashidCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jennifer L HallCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kirstin A TamucciCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-7033-807X
Zena ChatilaCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4383-6305
Minghua LiuCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Annie J LeeCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Badri N VardarajanCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-5560-4085
Mariko F TagaCenter for Translational and Computational Neuroimmunology, Departments of Neurology Columbia University Medical Center, New York, NY, USA.
Sirkku PollariSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7066-7052
Alon RabinovichDepartment of Neurobiology, George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.
Cory D RillahanDepartment of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Andrey A BobkovSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Eduard SergienkoSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
William MeadowsCambridge Institute for Medical Research, Cambridge, UK.
Seema QamarCambridge Institute for Medical Research, Cambridge, UK.
Suzanne J RandleCambridge Institute for Medical Research, Cambridge, UK.
Christopher M JohnsonMRC Laboratory of Molecular Biology, Cambridge, UK.
Jean SevalleDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jennifer GriffinDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Christopher BohmDepartment of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Mitsuhiko IkuraPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Xunde XianDepartment of Molecular Genetics, Center for Translational Neurodegeneration Research9, University of Texas Southwestern, Dallas, TX, USA.
Joachim HerzDepartment of Molecular Genetics, Center for Translational Neurodegeneration Research9, University of Texas Southwestern, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-8506-3400
Megan A KellySchool of Science, Faculty of Science, Medicine & Health, Molecular Horizons Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0002-0877-126X
Jennifer WestSchool of Science, Faculty of Science, Medicine & Health, Molecular Horizons Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0001-8708-921X
Sandeep SatapathySchool of Science, Faculty of Science, Medicine & Health, Molecular Horizons Research Institute, University of Wollongong, Wollongong, NSW, Australia.
Mark R WilsonSchool of Science, Faculty of Science, Medicine & Health, Molecular Horizons Research Institute, University of Wollongong, Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0002-9551-7445
Jonathan A JavitchDepartment of Psychiatry and Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7395-2967
Paul E FraserDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1227-4239
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Departments of Neurology Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Zvi FishelsonDepartment of Cell and Developmental Biology, Faculty of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0001-7097-6357
Dan FrenkelDepartment of Neurobiology, George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.
Wesley B AsherDepartment of Psychiatry and Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Wesley.Asher@nyspi.columbia.edu.ORCID http://orcid.org/0000-0001-7437-218X
Elizabeth M BradshawCarol and Gene Ludwig Center for Research on Neurodegeneration, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. emb2280@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-6766-4325
Peter St George-HyslopCambridge Institute for Medical Research, Cambridge, UK. phs22@cam.ac.uk.ORCID http://orcid.org/0000-0003-0796-7209
Funding
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377kGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 406915NIA NIH HHS K01 AG084849Wellcome TrustWellcome Trust (Wellcome) 203249/Z/16/Z
Abstract
Mechanisms linking CD33 variants to Alzheimer Disease (AD) are poorly defined. Here, we combine structural, cellular, and genetic analyses to delineate how the CD33
Indexed as
Alzheimer DiseaseClusterinSialic Acid Binding Ig-like Lectin 3Amyloid beta-PeptidesAnimalsApolipoproteins EHumansMicrogliaMonocytesPhosphorylationPlaque, AmyloidProtein BindingProtein IsoformsAmyloid beta-PeptidesApolipoproteins ECD33 protein, humanCLU protein, humanClusterinProtein IsoformsSialic Acid Binding Ig-like Lectin 3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.