Evidence map›Paper›PMID 42469213›Full record

Trial reportNature communications2026

Renal resistive index-guided mean arterial pressure titration in sepsis: a prospective single-center, single-blind, parallel-group randomized controlled trial.

Can Wang, Rong Li, Qiqi Li, Meng Wang, Yan Huo, Yaqi Han, Qian Zhang, Bingqi Lu, Zhenjie Hu, Xiaoting Wang and 3 more

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Can Wang *Department of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0006-3935-9231

Rong Li *Department of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Qiqi Li *Department of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Meng WangDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0000-3616-7687

Yan HuoDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0004-2523-2366

Yaqi HanDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0003-4696-9976

Qian ZhangDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0000-3721-7594

Bingqi LuDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0009-2255-0488

Zhenjie HuDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID http://orcid.org/0009-0009-2650-3275

Xiaoting WangDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0009-0001-0903-7809

Yangong ChaoDepartment of Critical Care Medicine, The First Affiliated Hospital of Tsinghua University, Beijing, China.ORCID http://orcid.org/0009-0005-5041-6463

Lixia LiuDepartment of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China. 47300535@hebmu.edu.cn.ORCID http://orcid.org/0009-0002-7237-2527

Chinese Critical Ultrasound Study Group (CCUSG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In sepsis, optimizing mean arterial pressure (MAP) for organ perfusion remains challenging. We conduct a single-center, single-blind, parallel-group randomized controlled trial enrolling 274 sepsis patients to evaluate whether renal resistive index (RRI)-guided MAP titration (MAP titration group, MTG) reduces 28-day all-cause mortality (primary endpoint) compared with conventional treatment (conventional treatment group, CTG). Post-titration, RRI decreases significantly in the MTG versus CTG (0.61 vs. 0.67, P < 0.001). However, 28-day mortality does not differ (25/138 vs. 36/136; RR 0.69, 95% CI 0.44-1.08; P = 0.11). These findings suggest that RRI-guided MAP titration improves renal hemodynamics but does not reduce mortality in this single-center trial; multicenter confirmation is warranted. (Chinese Clinical Trial Registry, ChiCTR2200057136, registered 1 March 2022; https://www.chictr.org.cn/showprojEN.html?proj=153154 ).

Indexed as

Arterial PressureKidneySepsisAgedFemaleHemodynamicsHumansMaleMiddle AgedProspective StudiesSingle-Blind MethodVascular Resistance

Identifiers

PMID42469213

DOI10.1038/s41467-026-75398-7

PMCPMC13493862

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.