Evidence map›Paper›PMID 42469200›Full record

ArticleCell death & disease2026

LARS regulates cellular senescence and autophagy in liver cancer cells.

Xiaodan Lin, Yanheng Chen, Caroline Hartmann, Lin-Feng Chen, Susan A Martinis

Abstract read
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaodan LinDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Yanheng ChenDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0009-0005-1047-3199
Caroline HartmannDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Lin-Feng ChenDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA. lfchen@illinois.edu.ORCID http://orcid.org/0000-0003-1809-1580
Susan A MartinisDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA. martinis@illinois.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytoplasmic leucyl-tRNA synthetase (LARS) is known to catalyze the ligation of leucine to tRNA

Indexed as

Amino Acyl-tRNA SynthetasesAutophagyCellular SenescenceLiver NeoplasmsCell MovementCell ProliferationGene Expression Regulation, NeoplasticHep G2 CellsHumansMembrane Potential, MitochondrialOxidative StressReactive Oxygen SpeciesAmino Acyl-tRNA SynthetasesReactive Oxygen Species

Identifiers

PMID42469200
PMCPMC13658823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.