Evidence map›Paper›PMID 42469011›Full record

ArticleGenes & development2026

The basic helix-loop-helix transcription factor TCF4 recruits the Mediator complex to activate gonadal genes and drive ovarian development.

Eleanore V O'Neil, Shannon M Dupont, Huan Liang, Rohit Singh, Blanche Capel

Abstract read
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In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Eleanore V O'NeilDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.ORCID http://orcid.org/0000-0002-4919-2715
Shannon M DupontDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.ORCID http://orcid.org/0000-0003-4607-2715
Huan LiangDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.ORCID http://orcid.org/0009-0000-4846-2499
Rohit SinghDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.
Blanche CapelDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA blanche.capel@duke.edu.ORCID http://orcid.org/0000-0002-6587-0969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bipotential gonad is the precursor to the ovary and testis. In mice, gonad differentiation is initiated by commitment of presupporting cells into testicular Sertoli cells or ovarian granulosa cells. While

Indexed as

Gene Expression Regulation, DevelopmentalOvaryAnimalsFemaleForkhead Box Protein L2Granulosa CellsMaleMiceProtein BindingSertoli CellsTestisTranscription Factor 4Transcription Factor 7-Like 1 ProteinForkhead Box Protein L2Foxl2 protein, mouseTcf4 protein, mouseTranscription Factor 4Transcription Factor 7-Like 1 ProteindevelopmentgonadTCF4

Identifiers

PMID42469011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.