ArticleFunction (Oxford, England)2026
Constitutive mTORC1 activation in skeletal muscle increases inflammation but is not sufficient to impair glucose tolerance.
Erik D Marchant, Hanna Kalenta, Sean P Kilroe, Jacquelyn May, Wenjun Z Martini, Korri S Weldon, Zhao Lai, Blake B Rasmussen
Abstract read
In one paragraphArticle in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Erik D MarchantDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.
Hanna KalentaDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.
Sean P KilroeDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.
Jacquelyn MayDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.
Wenjun Z MartiniDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.
Korri S WeldonGreehey Children's Cancer Research Institute, University of Texas at San Antonio, San Antonio, Texas, United States.
Zhao LaiGreehey Children's Cancer Research Institute, University of Texas at San Antonio, San Antonio, Texas, United States.
Blake B RasmussenDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas at San Antonio, San Antonio, Texas, United States.ORCID 0000-0001-7854-5375 Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MIllumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600kNCI NIH HHS P30 CA054174NIA NIH HHS T32 AG021890NIH HHS S10 OD030311
6 · The paper itselfAbstract
Aberrant mechanistic target of rapamycin complex 1 (mTORC1) signaling in skeletal muscle has been implicated in aging and insulin resistance; however, it is not known whether chronic mTORC1 activation directly causes glucose intolerance. We tested the hypothesis that constitutive mTORC1 activation in mouse skeletal muscle impairs glucose homeostasis. Six-month-old female and male mice with tamoxifen-inducible, muscle-specific knockout of the DEP domain containing 5, GATOR1 subcomplex subunit gene (
Indexed as
Glucose IntoleranceInflammationMechanistic Target of Rapamycin Complex 1Muscle, SkeletalAnimalsFemaleGlucoseInsulin ResistanceMaleMiceMice, KnockoutOxidative StressSignal TransductionGlucoseMechanistic Target of Rapamycin Complex 1insulin resistancemitochondrial functionmTORC1skeletal muscle
Identifiers
PMID42468920
PMCPMC13459988
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