Evidence map›Paper›PMID 42468389›Full record

ArticleThe International journal on drug policy2026

Integrating evidence-based methamphetamine interventions into methadone clinics: Structural barriers and implementation opportunities.

Nguyen Thu Trang, Dinh Thi Thanh Thuy, Hoa Hong Nguyen, Han Dinh Hoe, Nguyen Huu Anh, Nguyen Bich Diep, Vu Minh Anh, Nguyen Truong Giang, Michael Li, Li Li and 4 more

Abstract read
In one paragraph

Article in The International journal on drug policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Nguyen Thu TrangCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam. Electronic address: trangthu@hmu.edu.vn.
Dinh Thi Thanh ThuyCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Hoa Hong NguyenInstitute of Medical and Pharmaceutical Education, Thu Dau Mot University, Vietnam.
Han Dinh HoeCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Nguyen Huu AnhCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Nguyen Bich DiepCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Vu Minh AnhCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Nguyen Truong GiangCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.
Michael LiCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Li LiDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, USA.
Chunqing LinDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, USA.
Do Van DungUniversity of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
Steve ShoptawCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Le Minh GiangCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Vietnam.

Funding

Screen, Treat and Retain People with Primary Meth Use Disorder at MMT Clinics (STAR-OM+)R01DA050486 · NIDA · HANOI MEDICAL UNIVERSITY · PI LE, GIANG M, SHOPTAW, STEVEN J · 2020 to 2024
$2.3M
NIDA NIH HHS R01 DA050486
6 · The paper itself

Abstract

backgroundIntegrating evidence-based methamphetamine interventions into methadone programs is critical to address increasing methamphetamine use among methadone patients. This study examined the barriers and facilitators of implementing such integration in Vietnam.

methodWe conducted a qualitative study nested within an adaptive trial, Screen, Treat and Retain Meth-Using People with Opioid Use Disorder in Methadone Clinics (STAR-OM), integrating evidence-based methamphetamine interventions into 15 methadone clinics. Seventy-six in-depth interviews were conducted with participants and methadone providers to seek their experience implementing or receiving the study interventions. Interview guides were based on the Consolidated Framework for Implementation Research. Data was analyzed using thematic analysis to identify and explore key themes.

resultsResults reflected a tension between strong clinical support for integrating methamphetamine interventions and substantial structural constraints. The main facilitator was the perceived impact of interventions driven by social accountability and engagement with peers, providers and family members. Key barriers operated primarily at structural levels and included: (1) restrictive policy environments despite local demand for intervention; (2) workforce precarity and limited financial resources, particularly for contingency management; and (3) logistical implementation challenges such as organizing group sessions, burdensome urine testing, falsified urine samples and limited use of SMS-based reminders.

conclusionWhile evidence-based methamphetamine interventions were widely perceived as beneficial, major barriers existed at the policy and program levels. Macro-level actions - such as advocating for more harm reduction - oriented drug policies and strengthening workforce capacity - alongside pragmatic, clinic-level implementation strategies are essential for the sustainable adoption and scale-up of evidence-based methamphetamine interventions within Vietnam's methadone program.

Indexed as

Amphetamine-Related DisordersMethadoneMethamphetamineOpioid-Related DisordersSubstance Abuse Treatment CentersAdultEvidence-Based PracticeFemaleHumansMaleOpiate Substitution TreatmentQualitative ResearchVietnamMethadoneMethamphetamineAddictionCFIRContingency managementDiffusion of innovationDrug policyHealth systemsWorkforce issues

Identifiers

PMID42468389
PMCPMC13413982

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.