Evidence map›Paper›PMID 42468143›Full record

ArticleJournal of natural products2026

Diacarnusins A-F, nor-Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus.

Rania Hasib Afana, Lilach Raijman-Nagar, Micha Ilan, Shmuel Carmeli

Abstract read
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rania Hasib AfanaSchool of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv6997801, Israel.
Lilach Raijman-NagarSchool of Zoology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv6997801, Israel.
Micha IlanSchool of Zoology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv6997801, Israel.ORCID 0000-0002-4188-4573
Shmuel CarmeliSchool of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv6997801, Israel.ORCID 0000-0002-9641-9943

Funding

NSFC-ISF 2628/16School of Chemistry NA
6 · The paper itself

Abstract

Six new nor-terpene endoperoxides, diacarnusins A-F (1-6), along with five known ones (7-11), were isolated from the extract of the Red Sea sponge Diacarnus erythraeanus, which presented cytotoxic activity against the colon carcinoma cell line. The structure elucidation was performed by analysis of mass spectrometric and 1D and 2D NMR data. The relative and absolute configurations of the stereocenters of the compounds were deduced based on the Capon and Macleod empirical rule and comparison of the sign of their specific rotations with those of endoperoxides with proven absolute configurations. The cytotoxicity of the pure compounds was evaluated against a panel of cancer cell lines. The structure elucidation and biological activity of the compounds are discussed.

Indexed as

Antineoplastic AgentsPeroxidesPoriferaTerpenesAnimalsDrug Screening Assays, AntitumorHumansIndian OceanMolecular StructureNuclear Magnetic Resonance, BiomolecularAntineoplastic AgentsPeroxidesTerpenes

Identifiers

PMID42468143
PMCPMC13532193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.