ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Influenza, which causes respiratory tract infections and related complications, poses a major threat to global public health. However, the rapid and accurate detection of influenza viruses in controlling the flu pandemic remains challenging, as current diagnostic methods are static and unable to distinguish between viable and nonviable virus or directly monitor viral replication dynamics. Herein, we report viral luminogenic reporters (VLRs) with chemiluminescence/fluorescence dual-response for non-invasive imaging and urinalysis of the H1N1 virus protease. VLR comprises a bicyclic dioxetane chemiluminophore signaling scaffold caged by a N-acetylneuraminic acid, which further hooks a renal clearable moiety (2-hydroxypropyl)-β-cyclodextrin. VLR achieves a limit of detection of 2.62 CCID
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