Trial reportRheumatology (Oxford, England)2026
The WORKWELL programme: a randomized controlled trial of job retention vocational rehabilitation for people with inflammatory arthritis.
Trial report in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03942783 (A Randomised Controlled Trial of Job Retention Vocational Rehabilitation for Employed People With Inflammatory Arthritis), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Randomised Controlled Trial of Job Retention Vocational Rehabilitation for Employed People With Inflammatory Arthritis: the WORKWELL Trial.
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Authors and funding
21 authors.
Funding
Abstract
objectivePeople with inflammatory arthritis (InfA) frequently experience work instability, absenteeism, and reduced productivity, culminating in early job loss. This study evaluated the effectiveness and cost-effectiveness of WORKWELL job retention vocational rehabilitation (JRVR) delivered by occupational therapists, compared with a control group receiving written self-help advice.
methodsA pragmatic, multicentre randomized controlled trial was conducted across 18 UK National Health Service (NHS) Trusts. Employed adults (n = 249) with InfA experiencing moderate to severe work instability were randomized (1:1) to intervention or control groups. WORKWELL included structured work assessment, individually tailored action plans, and interventions over 2-4 months. Follow-up was at 6, 12 and 36 months. The primary outcome was measured using the Work Limitations Questionnaire-25 (WLQ-25). Analyses used linear mixed-effects regression adjusted for baseline characteristics and occupational skill level. A NHS perspective was used for the within-trial cost-effectiveness analysis. Much of the trial was affected by the COVID-19 pandemic.
resultsAt 12 months, there was no significant difference in WLQ-25 between groups (adjusted mean difference: -1.8; 95% CI -7.4-3.8; P = 0.53), or in most secondary outcomes at 12 or 36 months. However, absenteeism showed a relative reduction of 46% at 12 months (P = 0.08), and employment retention at 36 months was higher in the intervention (93%) than in the control group (85%). The intervention was not cost-effective from an NHS perspective.
conclusionWORKWELL did not lead to improved work productivity compared with self-help advice. Future research should explore more flexible delivery methods, including digital tools, to support sustainable employment for people with InfA. A plain-language abstract is available in the supplementary material.
trial registrationClinicalTrials.gov, http://clinicaltrials.gov, NCT03942783. ISRCTN Registry, ISRCTN61762297, https://doi.org/10.1186/ISRCTN61762297.
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