ArticleOrganic letters2026
Photocatalytic Annulation of Primary Amines to δ-Lactams: Access to Privileged (Spiro)piperidine Space.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Photocatalytic Annulation of Primary Amines to δ-Lactams: Access to Privileged (Spiro)piperidine Space.Organic letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Piperidines are the most prevalent saturated nitrogen heterocycles in pharmaceuticals, yet efficient and general methods for accessing α-disubstituted and spirocyclic variants have remained a long-standing synthetic challenge. A broadly applicable annulation strategy from unprotected primary alkylamines would represent an important advance, enabling access to privileged piperidine scaffolds from the most accessible nitrogen feedstocks. Here we disclose a general photoredox/hydrogen atom transfer dual catalytic annulation that converts primary amines into α-mono- and α-disubstituted δ-lactams, versatile intermediates that provide streamlined access to diverse piperidines. The method proceeds under mild conditions, can be scaled to ∼100 g in continuous flow, and affords products capable of downstream modification. This work provides a broadly applicable solution to a challenging problem in heterocycle synthesis, expanding the structural space accessible to drug discovery.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.