Evidence map›Paper›PMID 42467774›Full record

ArticleScience advances2026

Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemic

Duncan J Berger, Sang-Kyu Park, Thomas Crellen, Tushabe John Vianney, Narcis B Kabatereine, James A Cotton, Richard Sanya, Alison Elliott, Edridah M Tukahebwa, Moses Adriko and 13 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMInternational journal for parasitology. Drugs and drug resistance · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Duncan J BergerWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-2017-6623
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-3875-1227
Thomas CrellenWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0003-2934-1063
Tushabe John VianneyDivision of Biomedical Engineering, University of Glasgow, Glasgow, UK.ORCID 0009-0003-4152-2550
Narcis B KabatereineVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.ORCID 0000-0001-7036-5716
James A CottonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0001-5475-3583
Richard SanyaImmunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute.ORCID 0000-0001-6348-9075
Alison ElliottImmunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute.ORCID 0000-0003-2818-9549
Edridah M TukahebwaVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.
Moses AdrikoVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.ORCID 0000-0001-9748-1207
Claire J StandleyCenter for Global Health Science and Security, Georgetown University, 3900 Reservoir Rd NW, Washington, DC, USA.ORCID 0000-0002-4291-9723
Anouk GouvrasGlobal Schistosomiasis Alliance, Podium Space-Ealing Cross, 85 Uxbridge Road, London, UK.ORCID 0000-0002-7857-4309
Safari Kinung'hiNational Institute for Medical Research (NIMR) Mwanza Centre, P.O. Box 1462, Mwanza, United Republic of Tanzania.ORCID 0000-0001-8902-0312
Muriel RaboneWolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.ORCID 0000-0002-8351-2313
Aidan EmeryWolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.ORCID 0000-0001-9028-8586
Poppy H L LambertonSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK.ORCID 0000-0003-1048-6318
Bonnie L WebsterWolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.ORCID 0000-0003-0930-9314
Fiona AllanWolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.ORCID 0000-0001-6836-4124
Sarah BuddenborgWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-9506-9259
Matthew BerrimanWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-9581-0377
Jonathan S MarchantDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6592-0877
Stephen R DoyleWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0001-9167-7532
Joanne P WebsterDepartment of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, London, UK.ORCID 0000-0001-8616-4919

Funding

Resolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1M
NIAID NIH HHS R01 AI145871Wellcome Trust
6 · The paper itself

Abstract

Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control and elimination efforts. To assess how long-term MDA affects parasite populations, we analyzed whole-genome sequence data from 570

Indexed as

Drug ResistanceSchistosoma mansoniSchistosomiasis mansoniAnimalsAnthelminticsHumansPraziquantelAnthelminticsPraziquantel

Identifiers

PMID42467774
PMCPMC13378547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.