ArticleScience advances2026
PUM1 and PUM2 promote translation of chromatin regulators to ensure mammalian spermatogenesis.
Min Zang, Siyu Liu, Zhengyao Xie, Ding Yang, Ke Wang, Yan Ding, Tong Zhu, Shikun Zhang, Tingting Zhao, Bing Yao and 3 more
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Min ZangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0009-0004-6608-5438 Siyu LiuState Key Laboratory of Reproductive Medicine and Offspring Health, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China, 211166.ORCID 0000-0001-7089-2006 Zhengyao XieState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0000-0002-5380-8316 Ding YangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Ke WangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Yan DingState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Tong ZhuState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Shikun ZhangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0009-0006-0020-8989 Tingting ZhaoState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Bing YaoState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0000-0002-3420-2220 Mingxi LiuState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0000-0001-6499-7899 Kaibo LinDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200021.ORCID 0000-0002-2001-8369 Eugene Yujun XuState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.ORCID 0000-0002-4344-6606 Funding
Functional Genomic Approach to Male ContraceptionU01HD045871 · NICHD · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI XU, EUGENE Y · 2004 to 2008
$1.4MNICHD NIH HHS U01 HD045871
6 · The paper itselfAbstract
Translational control is essential for male germ cell development, yet how post-transcriptional regulation is coupled to chromatin remodeling during spermatogenesis remains poorly understood. Here, we show that the RNA-binding proteins PUMILIO1 (PUM1) and PUMILIO2 (PUM2) promote translation of mRNAs encoding chromatin regulators in the mouse testis. Conditional deletion of
Indexed as
ChromatinProtein BiosynthesisRNA-Binding ProteinsSpermatogenesisAnimalsHistonesMaleMiceRNA, MessengerTestisChromatinHistonesPum2 protein, mousepumilio 1 protein, mouseRNA-Binding ProteinsRNA, Messenger
Identifiers
PMID42467772
PMCPMC13378543
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