ArticlePloS one2026
TNF-α exacerbates postoperative plantar pain by regulating the expression of Nav1.8.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Postoperative pain (POP) is one of the most common complications of surgical procedures. Using a rat plantar incision model, we investigated the interactions between tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and the voltage-gated sodium channel Nav1.8, to uncover the neural basis of POP. Our research demonstrates that, within the dorsal root ganglion (DRG), TNF-α enhances pain behaviors by driving NF-κB-dependent overexpression of Nav1.8 in neurons, further elucidating the molecular basis of POP. This study identifies the TNF-α/NF-κB/Nav1.8 axis as a critical pathway for therapeutic intervention, thereby establishing a theoretical foundation for targeting cytokine signaling to alleviate POP.
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