Evidence map›Paper›PMID 42467310›Full record

ArticleMolecular diversity2026

Synthesis,

Basant G Salib, Basma M Essa, Hesham A Shamsel-Din, Mohamed A Motaleb, M El-Tawoosy, Adli A Selim, Sameh Ahmed Rizk, Ahmed Hassan Ibrahim Faraag, Mohamed A Ali, Islam Yousif Mostafa and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Basant G SalibChemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Basma M EssaRadioactive Isotopes and Generators Department, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Hesham A Shamsel-DinLabeled Compound Department, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
Mohamed A MotalebLabeled Compound Department, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
M El-TawoosyLabeled Compound Department, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
Adli A SelimLabeled Compound Department, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt. adli_a_selim@yahoo.com.ORCID https://orcid.org/0000-0001-7095-5978
Sameh Ahmed RizkChemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Ahmed Hassan Ibrahim FaraagBotany and Microbiology Department, Faculty of Science, Helwan University, Cairo, Egypt.
Mohamed A AliSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Islam Yousif MostafaDepartment of Microbiology, Faculty of Dentistry and Oral Medicine, Future University, Cairo, Egypt.
Reda MansourSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Salah S ElyanSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Mohamed Salah BasiounySchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Kurls E AnwerChemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To address the rise of multidrug-resistant bacteria by developing novel antibacterial agents with integrated capabilities for targeted delivery and real-time tracking, and to evaluate their potential for infection theranostics. Novel enaminonitrile-based pyridine and pyran derivatives were sustainably synthesized. Among them, lead compound 5 was assessed for in vitro DNA gyrase inhibition. Compound 5 was then radiolabeled with iodine-131, and radiolabeling yield was measured. In vivo biodistribution and pharmacokinetic profile were evaluated using an inflammatory murine model, with target-to-muscle ratios calculated. Compound 5 showed potent DNA gyrase inhibition (IC

Indexed as

Antibacterial agentsDNA gyrase inhibitionEnaminonitrileMechanochemical synthesisPharmacokinetic studyTheranostics

Identifiers

PMID42467310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.