Evidence map›Paper›PMID 42467251›Full record

ArticlePediatric surgery international2026

Pulse pressure as an early mortality predictor in neonates with congenital diaphragmatic hernia on veno-arterial ECMO.

Kyusang Yoo, Jeong Min Lee, Tae-Gyeong Kim, Jiyoon Jeong, Soo Hyun Kim, Euiseok Jung, Byong Sop Lee

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kyusang Yoo *Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Jeong Min Lee *Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Tae-Gyeong KimDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Jiyoon JeongDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Soo Hyun KimDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Euiseok JungDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Byong Sop LeeDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. mdleebs@amc.seoul.kr.ORCID https://orcid.org/0000-0002-1347-4200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEarly prognostic markers for pediatric patients receiving extracorporeal membrane oxygenation (ECMO), particularly those with congenital diaphragmatic hernia (CDH), remain poorly defined. This study aimed to evaluate pulse pressure (PP) as an early hemodynamic indicator of mortality in neonates with CDH undergoing veno-arterial (VA) ECMO.

methodsWe retrospectively analyzed newborns who underwent VA ECMO as primary rescue therapy for isolated CDH. Perinatal characteristics, arterial blood gas parameters, and blood pressure (BP) during the first 48 h post-ECMO were evaluated and compared between survivors and non-survivors.

resultsAmong 33 neonates, 20 (60.6%) survived. ECMO flow rates or systolic, diastolic, and mean BP did not differ between the group. However, PP at 24 h (20.0 mmHg [17.8-26.3] vs. 12.0 mmHg [10.0-13.0], p < 0.001) and 48 h (24.0 mmHg [20.0-28.8] vs. 12.0 mmHg [10.0-14.0], p < 0.001) post-ECMO was significantly higher in survivors. Receiver operating characteristic analysis demonstrated that PP was am early predictor of survival, with optimal cutoff values of 20 mmHg at 24 h and 17 mmHg at 48 h.

conclusionEarly recovery of PP was a strong predictor of survival in neonates with CDH requiring VA-ECMO. Further research is required to determine whether interventions to enhance pulsatility can improve clinical outcomes in this high-risk population.

Indexed as

Blood PressureExtracorporeal Membrane OxygenationHernias, Diaphragmatic, CongenitalFemaleHumansInfant, NewbornMalePrognosisRetrospective StudiesSurvival RateCongenital diaphragmatic herniaExtracorporeal membrane oxygenationHemodynamic parameterNeonatesPulse pressureUrine output

Identifiers

PMID42467251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.