Vestibular hair cell redundancy and the critical requirement of type I cells for balance maintenance.

Yikang Huang, Wenli Ni, Qin Zhou, Mingchuan Feng, Tao Jiang, Shunji He, Yan Chen, Wenyan Li

Abstract read

In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yikang Huang *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Wenli Ni *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Qin Zhou *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Mingchuan Feng *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Tao JiangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Shunji HeENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Yan ChenENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China. chenyan0528@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1228-7526

Wenyan LiENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China. wenyan_li@fudan.edu.cn.

Funding

National Key R&D Program of China 2025YFC3508205National Natural Science Foundation of China 82271159National Natural Science Foundation of China 82425018, 82271170, 82192861STI2030-Major Projects 2022ZD0205400

6 · The paper itself

Abstract

Vestibular hair cells (HCs) are sensory mechanotransducers essential for balance and spatial orientation, yet the relative contributions of HC number and subtype to vestibular function remain unresolved. Here, we developed a dose-dependent injury model in adult Pou4f3

Indexed as

Hair Cells, VestibularPostural BalanceAnimalsBasic Helix-Loop-Helix ProteinsDiphtheria ToxinDNA-Binding ProteinsHomeodomain ProteinsMiceMice, Inbred C57BLMice, TransgenicNitrilesTranscription Factor Brn-3CTranscription Factors3,3'-iminodipropionitrileAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsDiphtheria ToxinDNA-Binding ProteinsGfi1 protein, mouseHomeodomain ProteinsNitrilesPou4f3 protein, mouseTranscription Factor Brn-3CTranscription FactorsBalanceCell subtypeHair cellsMouse modelVestibular function

Identifiers

PMID42467221

DOI10.1007/s00018-026-06348-1

PMCPMC13661832

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.