Evidence map›Paper›PMID 42467213›Full record

ArticleSurgery today2026

Association of the absolute lymphocyte count-to-fibrinogen ratio with the survival outcomes in patients with colorectal cancer.

Masaya Inoue, Yasuhiro Takano, Keisuke Goto, Shu Tsukihara, Teppei Kamada, Yasuhiro Takeda, Masahisa Ohkuma, Makoto Kosuge, Ken Eto

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Masaya InoueDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yasuhiro TakanoDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. y.takano1864@jikei.ac.jp.ORCID http://orcid.org/0000-0001-7474-3833
Keisuke GotoDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Shu TsukiharaDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Teppei KamadaDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yasuhiro TakedaDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Masahisa OhkumaDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Makoto KosugeDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Ken EtoDepartment of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi- Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the prognostic impact of the absolute lymphocyte count-to-fibrinogen ratio (LFR) in patients undergoing curative resection for colorectal cancer.

methodsData from patients who underwent curative resection for colorectal cancer were retrospectively analyzed. The patients were divided into high and low LFR groups, and the relationships between LFR, disease-free survival (DFS), and overall survival (OS) were evaluated. Survival curves were generated using the Kaplan-Meier method, and multivariate analyses using Cox proportional hazards models were performed to identify the independent prognostic factors.

resultsPreoperative LFR was significantly associated with DFS and OS (both P < 0.01) after curative resection of colorectal cancer. A multivariate analysis revealed that the depth of invasion (T3 or T4) (P < 0.01, P = 0.02), lymph node metastasis (both P < 0.01), and LFR (both P < 0.01) were independent predictors of DFS and OS. In addition, patients in the low LFR group showed significantly higher inflammatory status and poorer nutritional profiles, including higher neutrophil-to-lymphocyte and C-reactive protein-to-albumin ratios (both P < 0.01) and lower prognostic nutritional index (P < 0.01) than those in the high LFR group.

conclusionsPreoperative LFR can be a prognostic factor for a poor postoperative prognosis in patients with colorectal cancer, suggesting an important role for LFR in assessing nutritional and inflammatory status.

Indexed as

Colorectal cancerLymphocyte count-to-fibrinogen ratioSurvival

Identifiers

PMID42467213

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.