Evidence map›Paper›PMID 42467196›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Corneal nerve regeneration and ocular surface restoration following treatment with autologous serum eye drops in patients with paralytic lagophthalmos and neurotrophic keratitis.

Luca Lucchino, Elvia Mastrogiuseppe, Francesca Giovannetti, Mattia D'Andrea, Giulia Mecarelli, Alice Bruscolini, Alessandro Lambiase, Marco Marenco

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Luca LucchinoDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Elvia MastrogiuseppeDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. elvia.mastrogiuseppe@uniroma1.it.ORCID http://orcid.org/0000-0001-9280-5153
Francesca GiovannettiDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Mattia D'AndreaDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Giulia MecarelliDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Alice BruscoliniDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Alessandro LambiaseDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
Marco MarencoDepartment of Sense Organs, Sapienza - University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effect of 20% autologous serum eye drops (ASED) in improving ocular surface condition and promoting corneal nerve regeneration in patients with Paralytic Lagophthalmos (PL) and Neurotrophic Keratitis (NK).

methodsThis prospective study included 11 patients with unilateral NK and PL treated with 20% ASED for 2 months. Ocular surface assessment included Schirmer I test, non-invasive tear film break-up time (NIBUT), Oxford staining score, Ocular Surface Disease Index (OSDI) and corneal esthesiometry. In vivo confocal microscopy (IVCM) was used to quantify changes in corneal subbasal nerve plexus, evaluating corneal nerve fiber length (CNFL), nerve fiber density (CNFD), and nerve branch density (CNBD). Pre- and post-treatment values were compared.

resultsTen patients completed the study. ASED treatment significantly improved Schirmer I values (mean: 10.3 ± 4.7 mm to 19.7 ± 12.1 mm; p = 0.041), OSDI scores (21.1 ± 12.9 to 17.0 ± 10.0; p = 0.009), and corneal sensitivity readings (central esthesiometry: 3.4 ± 1.9 mm to 5.0 ± 1.2 mm; p = 0.005). IVCM revealed significant increases in CNFL (11.1 ± 6.4 to 14.7 ± 7.3 mm/mm²; p = 0.006) and CNFD (23.1 ± 13.2 to 33.8 ± 11.9 fibers/mm²; p = 0.012). One patient discontinued treatment due to ocular discomfort.

conclusionTopical 20% ASED improved both functional and structural parameters in patients with PL and NK, suggesting neuroregenerative potential. These findings support the use of ASED as a therapeutic option in complex ocular surface disease, with IVCM as a valuable tool for monitoring nerve recovery.

Indexed as

Autologous serum eye drops (ASED)Corneal nerve regenerationIn vivo confocal microscopy (IVCM)Neurotrophic keratitis (NK)Paralytic lagophthalmos (PL)

Identifiers

PMID42467196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.