Evidence map›Paper›PMID 42467191›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Design and synthesis of pyrrolo[2,3-d]pyrimidine linked diazospiro and piperazine - piperidine libraries as anticancer agents.

Sridhar Guda, Srilakshmi V Patri, Krishna Reddy V, Vishnu Thumma, Santosh Kumar Guru

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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Sridhar GudaDepartment of Chemistry, National Institute of Technology, Warangal, 5060004, Telangana, India.
Srilakshmi V PatriDepartment of Chemistry, National Institute of Technology, Warangal, 5060004, Telangana, India. patrisrilakshmi@nitw.ac.in.ORCID https://orcid.org/0000-0002-9179-3768
Krishna Reddy VMedicinal Chemistry Laboratory Division, Aragen Life Sciences Pvt Ltd, IDA Mallapur, Hyderabad, 500076, Telangana, India.
Vishnu ThummaDepartment of Sciences and Humanities, Matrusri Engineering College, Hyderabad, 500059, Telangana, India.
Santosh Kumar GuruNational Institutes of Pharmaceutical Education and Research, Hyderabad, 500037, Telangana, India.

Funding

Scheme for Promotion of Academic and Research Collaboration SPARC/2024-2025/HCARE/P3444
6 · The paper itself

Abstract

Three libraries containing pyrrolo[2,3-d]pyrimidine moiety linked to diazospiro[3.5]nonane, diazospiro[5.5]undecane and piperazine - piperidine hybrid derivatives were synthesized involving various N-deprotection and acid amine coupling reactions. They were tested for their invitro cytotoxicity against triple negative human breast cancer cells MDA-MB-231 and BT-549. Promising results were obtained by pyrrolo[2,3-d]pyrimidine linked diazospiro[3.3]nonane compounds (7a and 7c) containing ortho-trifluoro and meta-bromo functional groups against MDA-MB-231 cells. Their dose response curves were plotted and their IC

Indexed as

Antineoplastic AgentsDrug DesignPiperazinesPiperidinesPyrimidinesPyrrolesSmall Molecule LibrariesSpiro CompoundsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructurePiperazineStructure-Activity RelationshipAntineoplastic AgentsPiperazinePiperazinespiperidinePiperidinesPyrimidinesPyrrolesSmall Molecule LibrariesSpiro CompoundsAcridine orange strainingCytotoxicityDiazospiro[3.3]nonaneDiazospiro[5.5]undecanePyrrolo[2,3-d]pyrimidineRhodamine 123 straining

Identifiers

PMID42467191

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.