ArticleOphthalmology and therapy2026
Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.
Article in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIntravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is a standard treatment for neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO). A transient rise in intraocular pressure (IOP) following injection is a well-established short-term effect. Aflibercept 8 mg has recently been introduced in a prefilled syringe (PFS), although data on its short-term effect on IOP are still lacking. The aim of this study was to assess short-term IOP changes after intravitreal aflibercept 8 mg administered via PFS and to compare these results with historical cohorts receiving aflibercept 8 mg via standard syringe and aflibercept 2 mg via PFS.
methodsThis single-centre comparative observational cohort study included a prospectively enrolled cohort of patients with nAMD or DMO receiving aflibercept 8 mg via PFS (0.07 mL), while two retrospective historical cohorts receiving aflibercept 8 mg via standard syringe (0.07 mL) or aflibercept 2 mg via PFS (0.05 mL) were used for comparison. IOP was measured with the iCare IC200 rebound tonometer at baseline (T0), 30 s (T1), 5 min (T2), and 15 min (T3) post-injection. Patients with glaucoma or ocular hypertension were excluded. Statistical analysis was performed using Friedman and Kruskal-Wallis tests.
resultsForty-six eyes treated with aflibercept 8 mg PFS were analysed. Baseline IOP was similar across the three groups (p = 0.54). In the aflibercept 8 mg PFS cohort, mean IOP increased from 13.92 ± 4.25 mmHg at baseline to 51.29 ± 15.07 mmHg at 30 s, then fell to 31.32 ± 12.24 mmHg at 5 min and to 20.25 ± 7.08 mmHg at 15 min (p < 0.001). No statistically significant between-group differences were detected at any timepoint (all p ≥ 0.18).
conclusionIntravitreal aflibercept 8 mg administered via PFS was associated with a transient rise in IOP immediately after injection, which resolved within 15 min and was similar to that observed with aflibercept 2 mg via PFS and aflibercept 8 mg via standard syringe. These findings contribute to the characterization of the short-term IOP response associated with aflibercept 8 mg PFS administration and may help inform routine clinical practice.
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