Evidence map›Paper›PMID 42467092›Full record

ArticleInternational orthopaedics2026

Association between central sensitization-related symptoms and pressure pain thresholds at local and remote sites in patients with knee osteoarthritis.

Junji Nishimoto, Rina Nakagawa, Rikumi Kurahashi, Ryo Tanaka

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Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Junji NishimotoDepartment of Rehabilitation, Faculty of Health Sciences, Tokyo Kasei University, Sayama, Japan. nishimoto-j@tokyo-kasei.ac.jp.ORCID 0000-0002-4830-0120
Rina NakagawaDepartment of Rehabilitation, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Rikumi KurahashiDepartment of Rehabilitation, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Ryo TanakaGraduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCentral sensitization (CS)-related symptoms are associated with pain severity and disability in patients with knee osteoarthritis (KOA). However, the associations between CS-related symptoms and pressure pain threshold (PPT) measurements at local and remote sites remain unclear. This study investigated the associations between CS-related symptoms and PPTs at local and remote sites in patients with KOA.

methodsThis cross-sectional study included patients with KOA scheduled for primary unilateral total knee arthroplasty. CS-related symptoms were assessed using the Central Sensitization Inventory (CSI), and PPTs were measured at local (knee) and remote (forearm) sites. Multiple linear regression analyses were performed with CSI score as the independent variable and local and remote PPTs as dependent variables, adjusting for potential confounders. Regression coefficients and 95% confidence intervals (CIs) were estimated by bootstrap resampling with 10,000 iterations.

resultsA total of 121 patients were included in the final analysis. Higher CSI scores were not associated with local PPTs (B = - 0.284, 95% CI: - 0.616 to 0.047, P = 0.080). In contrast, higher CSI scores were associated with lower remote PPTs (B = - 0.287, 95% CI: - 0.499 to - 0.070, P = 0.015).

conclusionsGreater CS-related symptom severity was associated with lower remote PPTs but not local PPTs in patients with KOA. These findings suggest that CS-related symptoms may reflect widespread pain hypersensitivity rather than localized pain sensitivity in patients with KOA.

Indexed as

Central Nervous System SensitizationOsteoarthritis, KneePain ThresholdAgedArthroplasty, Replacement, KneeCross-Sectional StudiesFemaleHumansMaleMiddle AgedNociplastic PainPain MeasurementPressureSeverity of Illness IndexCentral sensitizationKnee osteoarthritisPain hypersensitivityPressure pain threshold

Identifiers

PMID42467092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.