ReviewmSphere2026
Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs.
Review in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Antimicrobial resistance (AMR) is increasingly recognized as a One Health challenge driven by the continuous exchange of resistant bacteria and resistance determinants across human, animal, and environmental sectors. While genomic surveillance has substantially improved detection of antimicrobial resistance genes (ARGs), most monitoring frameworks remain gene- or isolate-centric, limiting insight into the mechanisms that govern resistance transmission and persistence. Recent evidence indicates that plasmids, self-replicating mobile genetic elements (MGEs) capable of horizontal transfer across bacterial species, play an important role in disseminating clinically relevant resistance determinants across sectors. In this mini-review, we synthesize genomic and ecological evidence demonstrating that a limited number of plasmid incompatibility (Inc) groups recur across human, animal, and environmental reservoirs, often independent of bacterial host lineages. We highlight how plasmid transmission dynamics are shaped by host-independent mobility, ecological generalism, co-selection with accessory traits, and persistence in engineered and natural environments. We further examine why current AMR surveillance approaches, including ARG-centric metagenomics and isolate-based monitoring, systematically overlook these plasmid-mediated processes. Furthermore, we propose that plasmid-resolved analysis represents a critical and currently underutilized complementary layer for One Health AMR surveillance. Integrating plasmid classification and genomic reconstruction into wastewater-based epidemiology and cross-sector monitoring frameworks can improve attribution of transmission pathways, enhance early detection of high-risk resistance, and provide a mechanistic foundation for risk-informed intervention strategies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.