Evidence map›Paper›PMID 42466907›Full record

ArticleMicrobiology spectrum2026

HBcAg-Induced IL-17F drives liver fibrosis in occult HBV infection.

Bochao Liu, Jieting Huang, Hualong Yang, Qiao Liao, Min Wang, Ru Xu, Zhengang Shan, Huishan Zhong, Fengfang Liao, Tingting Li and 4 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bochao Liu *Guangzhou Blood Center, Guangzhou, China.ORCID 0000-0003-3539-6618
Jieting Huang *Guangzhou Blood Center, Guangzhou, China.
Hualong YangGuangzhou Blood Center, Guangzhou, China.
Qiao LiaoGuangzhou Blood Center, Guangzhou, China.
Min WangGuangzhou Blood Center, Guangzhou, China.
Ru XuGuangzhou Blood Center, Guangzhou, China.
Zhengang ShanGuangzhou Blood Center, Guangzhou, China.
Huishan ZhongGuangzhou Blood Center, Guangzhou, China.
Fengfang LiaoGuangzhou Blood Center, Guangzhou, China.
Tingting LiDepartment of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.ORCID 0000-0001-5727-2179
Chengyao LiDepartment of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.ORCID 0000-0002-2087-873X
Huaqin LiangGuangzhou Blood Center, Guangzhou, China.
Yongshui FuGuangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-2199-2980
Xia RongGuangzhou Blood Center, Guangzhou, China.ORCID 0000-0002-2463-6340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While occult hepatitis B virus infection is a known risk factor for progressive liver diseases, the mechanistic basis for this association is poorly understood. To investigate this, we conducted a comparative study involving 40 OBI blood donors and 100 healthy blood donors to assess clinical parameters of liver fibrosis, including serum biomarkers, the FIB-4 index, and liver stiffness measurement. Transcriptome sequencing of peripheral blood mononuclear cells from these donors identified IL-17F as significantly upregulated in the OBI group. Mechanistically, we found that IL-17F was chiefly secreted by CD4

Indexed as

Hepatitis BHepatitis B Core AntigensHepatitis B virusInterleukin-17Liver CirrhosisCD4-Positive T-LymphocytesFemaleHepatic Stellate CellsHumansLeukocytes, MononuclearLiverMacrophagesMaleHepatitis B Core AntigensInterleukin-17HBcAgIL-17Fliver fibrosisoccult HBV infectiontranscriptome sequencing

Identifiers

PMID42466907
PMCPMC13435640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.