ArticleJournal of the American Heart Association2026
Age at Menarche and the Risk of Cardiac Events in Women With Congenital Long QT Syndrome.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundWomen with congenital long-QT syndrome (LQTS) experience increased risk of cardiac events (CE) after the onset of adolescence, possibly due to the effect of sex hormones on the cardiac ion channels. We hypothesized that late menarche may affect the risk of CE in women with LQTS.
methodsBeginning in 2010, information on age at menses onset was obtained from all women enrolled in the Rochester LQTS Registry. Multivariable modeling was employed to evaluate the association of age at menarche with the burden of CE (total number of syncope, aborted cardiac arrest, and LQTS-related sudden cardiac death) during the subsequent 20 years of follow-up. Menarche groups were defined as early (<12 years), normal (12-16 years), and late (>16 years).
resultsWe report data on 435 genetically confirmed LQTS women, of whom 68, 346, and 21 were in the early, normal, and late-onset groups, respectively. The mean cumulative rate of CE at 20 years of follow-up in women with late menarche was 28% and 64% higher than in women with normal or early menarche, respectively;
conclusionsLate menarche is associated with increased risk of CE in women with congenital LQTS. Further research is warranted to validate these findings and ascertain the explanatory pathophysiological pathways.
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