ArticleRespirology case reports2026
Treatment-Emergent Isolated EGFR C797S Mutation Following First-Line Osimertinib-Based Combination Therapy: A Case Report and Literature Review.
Article in Respirology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Treatment-Emergent Isolated EGFR C797S Mutation Following First-Line Osimertinib-Based Combination Therapy: A Case Report and Literature Review.Respirology case reports · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osimertinib is the standard first-line treatment for EGFR-mutated non-small cell lung cancer (NSCLC), although acquired resistance remains inevitable. The EGFR C797S mutation is a recognized on-target resistance mechanism; however, the T790M-negative/C797S-only subtype following frontline osimertinib-based combination therapy is rarely reported. We describe a 44-year-old Vietnamese never-smoking woman diagnosed with stage IV lung adenocarcinoma harbouring EGFR exon 21 L858R mutation. First-line treatment with pemetrexed-carboplatin plus osimertinib achieved a near-complete response, followed by maintenance osimertinib monotherapy. After 26 months of disease control, radiologic progression occurred with recurrent bilateral pulmonary metastases and right supraclavicular lymphadenopathy. Repeat biopsy and next-generation sequencing identified persistent EGFR L858R (VAF 13.92%) and acquired EGFR C797S (VAF 6.19%) without detectable T790M, consistent with a C797S-only resistance profile. Subsequent gefitinib plus bevacizumab therapy produced a rapid radiologic response with near-complete resolution of contralateral pulmonary lesions, suggesting retained sensitivity to reversible EGFR tyrosine kinase inhibitor-based therapy in C797S-only disease.
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Registered trials
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