Evidence map›Paper›PMID 42466399›Full record

ArticleResearch square2026

Neuronal Mitochondrial Dysfunction Drives Astrocytic Mitochondrial Transfer after TBI: Reveals the Therapeutic Potential of astrocytic EV-Mito.

Gopal V Velmurugan, Hemendra J Vekaria, Alexander G Rabchevsky, Kai Saito, Josh M Morganti, Samir Patel, Brad Hubbard, Patrick G Sullivan

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gopal V VelmuruganUniversity of Kentucky.
Hemendra J VekariaUniversity of Kentucky.
Alexander G RabchevskyUniversity of Kentucky.
Kai SaitoUniversity of Kentucky.
Josh M MorgantiUniversity of Kentucky.
Samir PatelUniversity of Kentucky.
Brad HubbardUniversity of Kentucky.
Patrick G SullivanUniversity of Kentucky.

Funding

Sustained eIF5A hypusination at the core of brain metabolic dysfunction in TDP-43 proteinopathiesP20GM148326 · NIGMS · UNIVERSITY OF KENTUCKY · PI Patrick G Sullivan · 2023 to 2026
$10.6M
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBIR01AG070830 · NIA · UNIVERSITY OF KENTUCKY · PI MORGANTI, JOSH · 2021 to 2025
$3.3M
Mitochondrial Uncoupling Prodrug as a Translational Therapy for TBIR01NS112693 · NINDS · UNIVERSITY OF KENTUCKY · PI KILBAUGH, TODD JUSTEN, SULLIVAN, PATRICK G · 2020 to 2025
$3.3M
Inflammatory contributions of astrocytic RelA in comorbid VCID/ADRF1NS118558 · NINDS · UNIVERSITY OF KENTUCKY · PI MORGANTI, JOSH · 2020 to 2021
$2.4M
BLRD VA I01 BX003405NIA NIH HHS R01 AG070830NIGMS NIH HHS P20 GM148326NINDS NIH HHS R01 NS112693NINDS NIH HHS RF1 NS118558
6 · The paper itself

Abstract

Mitochondria are dynamic organelles essential for neuronal survival and synaptic function, and their dysfunction is a key consequence of excitotoxicity following traumatic brain injury (TBI). While intercellular mitochondrial transfer and exogenous mitochondrial transplantation have emerged as mechanisms to restore cellular bioenergetics, its

Indexed as

cell-type specific mitochondriaexcitotoxicityexogenous mitochondrial transferextracellular vesicles containing mitochondria (EV-mito)Intercellular mitochondrial transferTBI

Identifiers

PMID42466399
PMCPMC13370613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.