Evidence map›Paper›PMID 42466234›Full record

ArticlePlastic and reconstructive surgery. Global open2026

Patient-reported Outcomes of Penile Inversion Vaginoplasty Using Post-Affirming Surgery Form and Function Individual Reporting Measure: A Retrospective Single-institution Study.

Nicole Sanchez Figueroa, Cesar A Gonzalez, Aidin Gharavi, Johanna L Ramirez, Vahe Fahradyan, Caroline J Davidge-Pitts, Jorys Martinez-Jorge

Abstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicole Sanchez FigueroaFrom the Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Cesar A GonzalezDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Transgender and Intersex Specialty Care Clinic, Mayo Clinic, Rochester, MN.
Aidin GharaviMayo Clinic Alix School of Medicine, Rochester, MN.
Johanna L RamirezDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Transgender and Intersex Specialty Care Clinic, Mayo Clinic, Rochester, MN.
Vahe FahradyanFrom the Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Caroline J Davidge-PittsDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Transgender and Intersex Specialty Care Clinic, Mayo Clinic, Rochester, MN.
Jorys Martinez-JorgeFrom the Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Penile inversion vaginoplasty (PIV) is a common gender-affirming procedure for transgender women, but validated, transgender-specific patient-reported outcomes remain limited. This study evaluated long-term outcomes after PIV using the Post-Affirming Surgery Form and Function Individual Reporting Measure (AFFIRM), a validated instrument assessing appearance, urologic, and gynecologic domains. Methods: We conducted a single-institution retrospective cohort with a cross-sectional, anonymous AFFIRM survey distributed in 2024. Demographics, perioperative outcomes, and complications were obtained by chart review. AFFIRM domain scores, reported on a 0-200 scale with lower scores indicating better outcomes, were analyzed descriptively. Results: Of 193 eligible patients who underwent PIV between 2017 and 2023, surveys were delivered to 186 patients, and 47.8% responded. Median age at surgery was 34.3 years (interquartile range 26.1-49.1), with a median follow-up time of 50.0 months. Most respondents reported high satisfaction with genital appearance, and 90% strongly agreed their anatomy aligned with gender identity. Clitoral sensation was reported by 93%, most commonly as pleasurable. Urologic symptoms were generally minimally bothersome; although 59% reported a misdirected urine stream, mean bother score was low (1.64 ± 1.77). Vaginal dryness and dyspareunia were reported by 43% and 44%, respectively, with 27% describing symptoms as bothersome. Major complications occurred in 13.9% and revision surgery in 34.2%, most commonly for stenosis or depth concerns (13.5%). Conclusions: AFFIRM captured meaningful, transgender-specific, long-term outcomes after PIV, complementing traditional surgical metrics and identifying opportunities to improve preoperative counseling, surgical refinement, and postoperative management of vaginal dryness and urinary symptoms.

Identifiers

PMID42466234
PMCPMC13375061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.