Premature Ovarian Insufficiency in a Patient With Vogt-Koyanagi-Harada Syndrome: An Unusual Association-A Case Report.

Premature ovarian insufficiency (POI) is a clinical syndrome characterized by ovarian failure in women of reproductive age before the age of 40 years. Its main manifestations include menstrual cycle disturbances, such as oligomenorrhea or amenorrhea. The etiology of POI is highly heterogeneous, with a particular emphasis on genetic and immunological factors. In addition, the condition may be associated with other rare diseases, such as Vogt-Koyanagi-Harada (VKH) syndrome. Our study aimed to describe a rare clinical case of a patient from Manaus, Amazonas, Brazil, who was simultaneously diagnosed with two rare conditions: POI and VKH syndrome, with a specific focus on their etiological characteristics, clinical manifestations, and laboratory findings. Clinical data were collected from the patient's medical record, as registered in the outpatient clinic database at Araújo Lima Hospital. Case description: The case involves a 38-year-old, nulliparous, mixed-race, married female patient diagnosed with POI and VKH syndrome. The understanding of these rare syndromes and the search for an integrated approach are fundamental to ensure better clinical outcomes, quality of life, and reproductive planning for affected patients. This report provides relevant information on the association between two rare syndromes, with the aim of contributing to medical decision-making and diagnostic clarification, as well as providing guidance on appropriate multidisciplinary follow-up. Thus, early diagnosis and appropriate treatment are essential steps in promoting this patient's health.