Evidence map›Paper›PMID 42466123›Full record

ArticleFrontiers in microbiology2026

Pseudorabies virus tegument protein pUL49 antagonizes cyclic GMP-AMP synthase through phase separation to promote viral replication.

Lipeng Gan, Yuan Gao, Lina Ma, Yutong Zhang, Shiyi Chai, Huiying Li, Mengting Zhang, Xinya Yang, Qingcui Xiao, Yinli Xie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lipeng Gan *School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuan Gao *School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lina Ma *School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yutong ZhangThe Second School of Clinical Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shiyi ChaiCixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China.
Huiying LiCixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China.
Mengting ZhangSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinya YangSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qingcui XiaoCixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China.
Yinli XieSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Longwei ZhaoSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Peng SunSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhiyong LiSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudorabies virus (PRV) is an economically important swine alphaherpesvirus with zoonotic potential. The mechanisms underlying PRV innate immune evasion remain poorly understood. Here, we identify the PRV tegument protein pUL49 as a critical viral factor that undergoes phase separation to antagonize cyclic GMP-AMP synthase (cGAS)-mediated antiviral signaling. pUL49 exhibits the strongest predicted phase-separation propensity and forms dynamic, 1,6-hexanediol (1,6-HEX)-sensitive condensates in cells. It colocalizes and interacts with cGAS, and its overexpression attenuates poly(dA:dT)-induced IFN-β signaling. Moreover, cGAS deficiency facilitates PRV replication, while pUL49 knockdown suppresses viral replication. These findings further elucidate our mechanistic understanding of PRV pUL49-mediated immune evasion and provide a potential target for developing antiviral strategies against PRV.

Indexed as

cGASphase separationpseudorabies viruspUL49viral replication

Identifiers

PMID42466123
PMCPMC13372753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.