ArticleJournal of diabetes and metabolic disorders2026
Association of hematologic-inflammatory indices and all-cause mortality in adults with type 2 diabetes and hypertension.
Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study examines the relationship between hematologic-inflammatory indices and all-cause mortality in individuals with type 2 diabetes and hypertension. Methods: Using data from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, 1,170 diabetic and 2,022 hypertensive participants were analyzed. The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte-platelet ratio (NLPR) were calculated from complete blood counts and assessed using Cox regression models and Kaplan-Meier curves. Results: Over 10 years, mortality rates were 11.3% in diabetic and 6.9% in hypertensive participants. In diabetic individuals, SII/100 was associated with mortality in both unadjusted and adjusted models (HR: 1.10, Conclusion: Hematologic-inflammatory indices, particularly NLR, were associated with all-cause mortality mainly among individuals with diabetes and those with both diabetes and hypertension; however, the associations varied by index and disease subgroup. Clinical trial number: Not applicable.
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