Evidence map›Paper›PMID 42466064›Full record

ArticleFindings of ACL. ACL2026

Faithfulness

Kaijie Mo, Siddhartha Venkatayogi, Chantal Shaib, Ramez Kouzy, Wei Xu, Byron C Wallace, Junyi Jessy Li

Abstract read
In one paragraph

Article in Findings of ACL. ACL, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaijie MoThe University of Texas at Austin.
Siddhartha VenkatayogiThe University of Texas at Austin.
Chantal ShaibNortheastern University.
Ramez KouzyMD Anderson Cancer Center.
Wei XuGeorgia Institute of Technology.
Byron C WallaceNortheastern University.
Junyi Jessy LiThe University of Texas at Austin.

Funding

Building Safety Guards into LLMs for Trustworthy Automatic Simplification of Medical DocumentsR01LM014600 · NLM · UNIVERSITY OF TEXAS AT AUSTIN · PI Junyi Jessy Li, BYRON CASEY WALLACE · 2024 to 2026
$1.0M
NLM NIH HHS R01 LM014600Wellcome Trust
6 · The paper itself

Abstract

In high-stakes domains like medicine, it may be generally desirable for models to faithfully adhere to the context provided. But what happens if the context does not align with model priors or safety protocols? In this paper, we investigate how LLMs behave and reason when presented with counterfactual (or even adversarial) medical evidence. We first construct MedCounterFact, a counterfactual medical QA dataset that requires the models to answer clinical comparison questions (i.e., judge the efficacy of certain treatments, with evidence consisting of randomized controlled trials provided as context). In MedCounterFact, real-world medical interventions within the questions and evidence are systematically replaced with four types of counterfactual stimuli, ranging from unknown words to toxic substances. Our evaluation across multiple frontier LLMs on MedCounterFact reveals that in the presence of counterfactual evidence, existing models overwhelmingly accept such "evidence" at face value even when it is dangerous or implausible, and provide confident and uncaveated answers. While it may be prudent to draw a boundary between faithfulness and safety, our findings suggest that models arguably overemphasize the former.

Identifiers

PMID42466064
PMCPMC13373577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.