Evidence map›Paper›PMID 42466003›Full record

ArticleFrontiers in pharmacology2026

Treatment of children with acute upper respiratory tract infection (wind-heat pattern) with Yin Hu Gan Mao San: a prospective real-world cohort study.

Jialin Li, Teng Huang, Lihua Ning, Gen Lu, Chunying Tan, Songhua Fang, Shan Hua, Zhenkun Zhang, Zhou Fu, Ping He and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jialin Li *China National Clinical Research Center of Respiratory Diseases Respiratory Department of Beijing Children's Hospital Capital Medical University National Center for Children's Health, Beijing, China.
Teng Huang *Pediatrics Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Lihua NingPediatrics Department, The Fourth Hospital of Baotou, Baotou, Inner Mongolia, China.
Gen LuRespiratory Department, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China.
Chunying TanPediatrics Department, Liaoning Maternal and Child Health Hospital, Shenyang, Liaoning, China.
Songhua FangEmergency Department, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Shan HuaRespiratory Medicine, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Zhenkun ZhangRespiratory Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China.
Zhou FuRespiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.
Ping HeRespiratory Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan, China.
Wei HouRespiratory Department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xian, Shaanxi, China.
Ya ZhouRespiratory Department Medical University Affiliated Shengjing Hospital Dalian Hospital, Dalian, Liaoning, China.
Tao YangRespiratory Department, Kunming Yanan Hospital, Kunming, Yunnan, China.
Hongfang LuoRespiratory Department, The Second Affiliated Hospital of Guizhou Medical University, Kaili City, Guizhou, China.
Huiyuan ZhangRespiratory Department, The Hospital of Shanxi University of Chinese Medicine, Taiyuan Shanxi, China.
Jun TangRespiratory Department, Guangzhou Liwan District Maternal and Child Health Hospital, Guangzhou, Guangdong, China.
Yun LiuRespiratory Department, Urumqi First People's Hospital, Urumqi, Xinjiang, China.
Rongchang ShaoRespiratory Department, Ezhou Central Hospital, Ezhou, Hubei, China.
Yourui DuRespiratory Department, Yuncheng Traditional Chinese Medicine Hospital, Yuncheng Shanxi, China.
Fujian LiaoRespiratory Department, Chongqing Yongchuan District Hospital of Traditional Chinese Medicine, Chongqing, China.
Xueming LiRespiratory Department, Handan Hospital of Traditional Chinese Medicine, Handan, Hebei, China.
Yanhong JiaPediatric Medicine, Shan Xi Fen Yang Hospital, Fenyang Shanxi, China.
Ming YanRespiratory Department, Jinzhou District First People's Hospital, Dalian Liaoning, China.
Hui ZhenRespiratory Disease Research Committee of China Association of Traditional Chinese Medicine, Beijing, China.
Junping DingHarbin Kangsaisi Medical Technology Development Co., Ltd., Harbin Heilongjiang, China.
Hongping ChenBeijing Yaohai Ningkang Pharmaceutical Technology Co., Ltd., Beijing, China.
Youjia XuPediatrics Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Baoping XuChina National Clinical Research Center of Respiratory Diseases Respiratory Department of Beijing Children's Hospital Capital Medical University National Center for Children's Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Yin Hu Gan Mao San (YHGMS) is a traditional Chinese herbal preparation derived from Yin Qiao San, used for topical application to treat wind-heat colds. This study aims to evaluate the clinical efficacy and safety of YHGMS in children with acute upper respiratory tract infection (AURTI) of wind-heat pattern. Methods: This prospective, real-world cohort study enrolled 999 children with AURTI from 23 hospitals from May 2022 to June 2023. Participants were naturally divided into an exposed group (n = 671) that received YHGMS and a non-exposed group (n = 328) that did not receive YHGMS or any other traditional Chinese medicine. Propensity score matching was used to balance baseline characteristics. Primary outcomes included clinical recovery rate and time to recovery. Secondary outcomes included time to normal temperature, symptom resolution rates, and safety profile. Results: After propensity score matching, the YHGMS group demonstrated significantly higher recovery rates on day 3 (52.64% vs Conclusion: YHGMS was associated with faster clinical recovery and symptom resolution in children with AURTI (wind-heat pattern), without significant safety concerns. As monotherapy, YHGMS showed better outcomes than chemical medicine alone; in combination, it also accelerated resolution of clinical symptoms and recovery.

Indexed as

acute upper respiratory tract infectionchildrencohort studyreal-world studywind-heat patternYin Hu Gan Mao San

Identifiers

PMID42466003
PMCPMC13372784

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