ArticleFrontiers in pharmacology2026
Elucidating the dual regulation of apoptosis and migration by Ajugasterone C in AGS cells via the PI3K/AKT pathway.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate the effects of Ajugasterone C (AC), a primary phytochemical of Methods: The anti-proliferative effect of AC was determined using the CCK-8 assay. Its effects on clonogenic survival, apoptosis, and migration were assessed via colony formation, Annexin V-FITC/PI flow cytometry, and scratch wound healing assays, respectively. The mechanism was explored by Western blotting of key PI3K/AKT pathway proteins (PI3Kα, total AKT1, and p-AKT1). Molecular docking and dynamics simulations were employed to predict the interaction between AC and the PI3Kα protein. Result: AC treatment significantly suppressed the proliferation of AGS cells in a concentration-dependent manner, with an IC Conclusion: AC exerts potent antitumor effects against gastric cancer AGS cells by inhibiting proliferation, inducing apoptosis, and suppressing migration, primarily through the inhibition of the PI3K/AKT signaling pathway. These findings suggest that AC may be a natural product with PI3K/AKT inhibitory potential, and could provide a preliminary molecular basis for further investigation into the traditional use of
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