ArticlemedRxiv : the preprint server for health sciences2026
Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder.
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Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
46 authors.
Katherine XuDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.ORCID 0000-0003-0344-2069
Atlas KhanDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Ning ShangDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Wenjie ZengDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Chen WangDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Cecilia BerrouetDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Tian Huai ShenDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Padma NarayananDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Jenny DengDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Chiara DiPernaDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Charlotte WilliamsDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Sarah CuacuasDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Timothy R OlsenBiohub; New York, NY, USA.
Jeffrey AraceDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Aryan GhotraDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Tai Wei GuoDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Wayne MonicalDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Oleg BorisovInstitute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg; Freiburg, Germany.
Stefan HaugInstitute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg; Freiburg, Germany.
Hongbo LiuDepartment of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0002-0733-8616
Eunji HaDepartment of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania; Philadelphia, PA, USA.
Andrew YaehDepartment of Medicine, Memorial Sloan Kettering Cancer Center; New York, NY, USA.
Run BanlengchitDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Abraham LevitmanDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Bartlomiej HalibartDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Diya PatelDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Claire ChouDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Shawn SimmonsDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Sanya GoswamiDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Kivanc NesanirDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Masashi FujitaDepartment of Neurology, Vagelos College of Physicians & Surgeons; Columbia University, New York, NY, USA.
Iftikhar J KulloDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin; Milwaukee, WI, USA.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, Division of Medical Genetics, University of Washington Medical Center; Seattle, Washington, USA.
Wei-Qi WeiDepartment of Medicine, Vanderbilt University Medical Center; Nashville, TN, USA.
QiPing FengDepartment of Medicine, Vanderbilt University Medical Center; Nashville, TN, USA.ORCID 0000-0002-6213-793X
Lan JiangDepartment of Medicine, Vanderbilt University Medical Center; Nashville, TN, USA.
C Michael SteinDepartment of Medicine, Vanderbilt University Medical Center; Nashville, TN, USA.
Chunhua WengDepartment of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
George HripcsakDepartment of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Ali G GharaviDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Katalin SusztakDepartment of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania; Philadelphia, PA, USA.
Philip L De JagerDepartment of Neurology, Vagelos College of Physicians & Surgeons; Columbia University, New York, NY, USA.
Anna KöttgenInstitute of Epidemiology and Prevention, Faculty of Medicine and Medical Center, University of Freiburg; Freiburg, Germany.
Jonathan BaraschDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Peter A SimsBiohub; New York, NY, USA.
Krzysztof KirylukDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University; New York, NY, USA.
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MVanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCI NIH HHS P30 CA013696NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG008680NHLBI NIH HHS R01 HL163854NIDDK NIH HHS K01 DK135917NIDDK NIH HHS K25 DK128563NIDDK NIH HHS R03 DK144285NIDDK NIH HHS T32 DK108741NIDDK NIH HHS TL1 DK136048NIDDK NIH HHS U54 DK104309NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196
Abstract
Urinary tract infections (UTIs) are traditionally viewed as environmentally driven, yet their inherited susceptibility remains largely unexplored. We conducted a cross-biobank genome-wide association study of recurrent UTIs in 1,860,836 individuals (213,869 cases and 1,646,967 controls). We identified 36 genetic susceptibility loci and performed tissue-based multi-omic mapping to prioritize candidate causal genes. UTI risk alleles preferentially modulated epithelial gene expression in kidney and bladder, converging on urinary epithelia structure and function.
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