Evidence map›Paper›PMID 42465941›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults.

Avinash S Mahajan, Sathyabaarathi Ravichandran, Radu Marches, Yilmaz Yucehan Yazici, Sean Nelson, Teresa Aydillo-Gomez, Kshitija Kshitija, Amaya Rojo-Fernandez, Djamel Nehar-Belaid, Lisa Kenyon-Pesce and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Avinash S MahajanThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Sathyabaarathi RavichandranThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Radu MarchesThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Yilmaz Yucehan YaziciThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Sean NelsonGale and Ira Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, USA.
Teresa Aydillo-GomezDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0003-3086-1058
Kshitija KshitijaThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Amaya Rojo-FernandezDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Djamel Nehar-BelaidThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Lisa Kenyon-PesceUConn Center on Aging, Farmington, CT, USA.
Daniel KlimesThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Haebeen JungThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
Peter SageDepartment of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Virginia PascualGale and Ira Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, USA.
Patrick WilsonGale and Ira Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.
George A KuchelUConn Center on Aging, Farmington, CT, USA.
Duygu UcarThe Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, USA.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)U19AI168631 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Harm van Bakel · 2022 to 2026
$14.4M
A deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0M
High-resolution single cell profiling of vaccine responsiveness in the elderlyR01AI142086 · NIAID · JACKSON LABORATORY · PI UCAR, DUYGU · 2019 to 2023
$2.9M
NIAID NIH HHS R01 AI142086NIAID NIH HHS U01 AI165452NIAID NIH HHS U19 AI168631NIH HHS 75N93021C00014
6 · The paper itself

Abstract

Despite the superior efficacy of high-dose influenza vaccines, over one-third of older adults fail to respond. Yet, the mechanisms underlying this impaired vaccine responsiveness remain poorly understood. Here, we performed longitudinal profiling of older adults (n=60) receiving high-dose influenza vaccination to identify immune programs associated with vaccine responsiveness. Strong responders exhibited a primed baseline immune state characterized by elevated plasma cytokines and chemokines, followed by enhanced IFN-γ responses and coordinated transcriptional and epigenetic activation of cDC2 cells at day 1. By day 7, CD4

Identifiers

PMID42465941
PMCPMC13370532

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.